日期 影响因子
日期:
2020 年 — 2026 年
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影响因子:
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Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias

药理偶联剂拯救血管加压素2受体突变体揭示了意想不到的组成型活性和偶联偏好性

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0181830
Janovick, Jo Ann; Spicer, Timothy P; Bannister, Thomas D; Scampavia, Louis; Conn, P Michael
信号转导
发表日期：2017
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Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

受体拮抗/激动作用可以与药理伴侣活性脱钩。

期刊:Molecular and Cellular Endocrinology
影响因子:3.6
doi:10.1016/j.mce.2016.07.003
Janovick, Jo Ann; Spicer, Timothy P; Smith, Emery; Bannister, Thomas D; Kenakin, Terry; Scampavia, Louis; Conn, P Michael
信号转导
发表日期：2016
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Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR

自噬质量控制机制会降解错误折叠的膜蛋白GnRHR的可溶性ERAD抗性构象体。

期刊:Molecular Cell
影响因子:16.6
doi:10.1016/j.molcel.2014.02.025
Houck, Scott A; Ren, Hong Yu; Madden, Victoria J; Bonner, Jacob N; Conlin, Michael P; Janovick, Jo Ann; Conn, P Michael; Cyr, Douglas M
自噬
发表日期：2014
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Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.

将药理伴侣转化为治疗用途：体内原理验证和高通量筛选设计

期刊:Pharmacological Research
影响因子:10.5
doi:10.1016/j.phrs.2013.12.004
Conn P Michael, Smithson David C, Hodder Peter S, Stewart M David, Behringer Richard R, Smith Emery, Ulloa-Aguirre Alfredo, Janovick Jo Ann
发表日期：2014
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A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor

一种用于鉴定促性腺激素释放激素受体药理伴侣的表型高通量筛选方法

期刊:ASSAY and Drug Development Technologies
影响因子:1.7
doi:10.1089/adt.2014.576
Conn, P Michael; Smith, Emery; Spicer, Timothy; Chase, Peter; Scampavia, Louis; Janovick, Jo Ann
信号转导
免疫/内分泌
发表日期：2014
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Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

通过药理伴侣药物疗法恢复携带错误折叠的 GnRHR 突变体的低促性腺激素性性腺功能减退小鼠的睾丸功能

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1315194110
Janovick, Jo Ann; Stewart, M David; Jacob, Darla; Martin, L D; Deng, Jian Min; Stewart, C Allison; Wang, Ying; Cornea, Anda; Chavali, Lakshmi; Lopez, Suhujey; Mitalipov, Shoukhrat; Kang, Eunju; Lee, Hyo-Sang; Manna, Pulak R; Stocco, Douglas M; Behringer, Richard R; Conn, P Michael
免疫/内分泌
发表日期：2013
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Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system

物种序列差异决定了GnRH受体与细胞质量控制系统的相互作用。

期刊:Molecular and Cellular Endocrinology
影响因子:3.6
doi:10.1016/j.mce.2013.07.012
Cabrera-Wrooman, Alejandro; Janovick, Jo Ann; Conn, P Michael
信号转导
细胞生物学
发表日期：2013
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High-throughput screen for pharmacoperones of the vasopressin type 2 receptor.

血管加压素2型受体药理伴侣的高通量筛选

期刊:Journal of Biomolecular Screening
影响因子:
doi:10.1177/1087057113483559
Conn P Michael, Smith Emery, Hodder Peter, Janovick Jo Ann, Smithson David C
心血管
发表日期：2013
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Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation

与促性腺激素释放激素受体激动剂结合位点重叠的盐桥揭示了G蛋白偶联受体激活的重合检测器

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1124/jpet.111.180869
Janovick, Jo Ann; Pogozheva, Irina D; Mosberg, Henry I; Conn, P Michael
信号转导
免疫/内分泌
发表日期：2011
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Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism

与家族性低促性腺激素性性腺功能减退症相关的人类促性腺激素释放激素受体突变体Thr104Ile和Tyr108Cys的发病机制的生化机制

期刊:Molecular and Cellular Endocrinology
影响因子:3.6
doi:10.1016/j.mce.2011.01.016
Maya-Núñez, Guadalupe; Janovick, Jo Ann; Aguilar-Rojas, Arturo; Jardón-Valadez, Eduardo; Leaños-Miranda, Alfredo; Zariñan, Teresa; Ulloa-Aguirre, Alfredo; Conn, P Michael
信号转导
免疫/内分泌
发表日期：2011
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