日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G

JNJ-78306358 是一种首创的双特异性 T 细胞接合抗体,靶向 CD3 和 HLA-G。

Nataša Obermajer ,Adam Zwolak ,Kelly van de Ven ,Shana Versmissen ,Krista Menard ,Katharine Rogers ,Ted Petley ,Dan Weinstock ,Jason Aligo ,Jaymala Patel ,Ken Tian ,Lorraine Angelillo ,Fang Yi ,Stephen Jarantow ,Keith Schutsky ,Yoshitomo Hamuro ,Diana Alvarez Arias ,Kristel Buyens ,Tsun-Wen Sheena Yao ,Vince Torti ,Aleksandra Brajic ,Brian Geist ,Marjolein van Heerden ,Gerald Chu ,Bie Verbist ,Maté Ongenaert ,Julien Häsler ,Kathryn Packman ,Jacintha Shenton ,Laurie Lenox ,Jacalyn Clawson ,Regina J Brown ,Josh Lauring ,James G Greger ,Dirk Brehmer ,Sanjaya Singh ,Matthew V Lorenzi ,Sylvie Laquerre

Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

一种新型变构激动剂/增敏剂胰岛素受体单克隆抗体的独特药理学特性

Hinke, Simon A; Cieniewicz, Anne M; Kirchner, Thomas; D'Aquino, Katharine; Nanjunda, Rupesh; Aligo, Jason; Perkinson, Robert; Cooper, Philip; Boayke, Ken; Chiu, Mark L; Jarantow, Steve; Lacy, Eilyn R; Liang, Yin; Johnson, Dana L; Whaley, Jean M; Lingham, Russell B; Kihm, Anthony J

Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance

新型单克隆抗体是一种诱导胰岛素抵抗的变构胰岛素受体拮抗剂

Anne M Cieniewicz, Thomas Kirchner, Simon A Hinke, Rupesh Nanjunda, Katharine D'Aquino, Ken Boayke, Philip R Cooper, Robert Perkinson, Mark L Chiu, Stephen Jarantow, Dana L Johnson, Jean M Whaley, Eilyn R Lacy, Russell B Lingham, Yin Liang, Anthony J Kihm

Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells

Fc 介导的 EGFR x c-Met 双特异性抗体 JNJ-61186372 增强对肺癌细胞的杀伤作用

Katharine D Grugan, Keri Dorn, Stephen W Jarantow, Barbara S Bushey, Jose R Pardinas, Sylvie Laquerre, Sheri L Moores, Mark L Chiu

Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody

EGFR x c-Met 双特异性抗体的交叉臂结合效率

Zheng, Songmao; Moores, Sheri; Jarantow, Stephen; Pardinas, Jose; Chiu, Mark; Zhou, Honghui; Wang, Weirong

Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody

细胞表面抗原表达对表皮生长因子受体×c-MET 双特异性抗体靶标结合和功能的影响

Stephen W Jarantow, Barbara S Bushey, Jose R Pardinas, Ken Boakye, Eilyn R Lacy, Renouard Sanders, Manuel A Sepulveda, Sheri L Moores, Mark L Chiu

Three-dimensional lung tumor microenvironment modulates therapeutic compound responsiveness in vitro--implication for drug development

三维肺肿瘤微环境调节体外治疗化合物的反应性——对药物开发的意义

Jason E Ekert, Kjell Johnson, Brandy Strake, Jose Pardinas, Stephen Jarantow, Robert Perkinson, David C Colter

Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo

生成和选择新型全人源单克隆抗体,在体外中和 Dickkopf-1 (DKK1) 抑制功能并在体内增加骨量

Helmut Glantschnig, Richard A Hampton, Ping Lu, Jing Z Zhao, Salvatore Vitelli, Lingyi Huang, Peter Haytko, Tara Cusick, Cheryl Ireland, Stephen W Jarantow, Robin Ernst, Nan Wei, Pascale Nantermet, Kevin R Scott, John E Fisher, Fabio Talamo, Laura Orsatti, Alfred A Reszka, Punam Sandhu, Donald Kimme