Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in naïve mice
病毒载体增强 OmcB 或 CPAF 特异性 T 细胞反应未能提高感染免疫小鼠对鼠衣原体的保护力,反而会在未感染小鼠中诱导出无保护作用的 CD8 优势反应。
期刊:Mucosal Immunology
影响因子:7.6
doi:10.1016/j.mucimm.2024.06.012
Poston, Taylor B; Girardi, Jenna; Polson, A Grace; Bhardwaj, Aakash; Yount, Kacy S; Jaras Salas, Ian; Trim, Logan K; Li, Yanli; O'Connell, Catherine M; Leahy, Darren; Harris, Jonathan M; Beagley, Kenneth W; Goonetilleke, Nilu; Darville, Toni
T细胞
炎症/感染
CD8
微生物学
细胞生物学
免疫/内分泌