日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus

通过使用 RosettaAntibodyDesign (RAbD) 设计抗体 80R 的特异性开关,计算设计针对多种 SARS-CoV-2 变体的纳摩尔结合抗体,从而为新型 SARS-CoV-2 病毒提供潜在的可推广治疗性抗体

Nancy E Hernandez, Wojciech Jankowski, Rahel Frick, Simon P Kelow, Joseph H Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D Khare, Roland L Dunbrack Jr, Jeffrey J Gray, Zuben E Sauna

Complete Combinatorial Mutational Enumeration of a protein functional site enables sequence-landscape mapping and identifies highly-mutated variants that retain activity

蛋白质功能位点的完整组合突变枚举可以实现序列景观映射,并识别保留活性的高度突变变体

Mireia Solà Colom, Jelena Vucinic, Jared Adolf-Bryfogle, James W Bowman, Sébastien Verel, Isabelle Moczygemba, Thomas Schiex, David Simoncini, Christopher D Bahl

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

利用核酸递送免疫靶向SARS-CoV-2纳米颗粒,可快速有效地诱导免疫反应,实现单剂量保护。

Kylie M Konrath ,Kevin Liaw ,Yuanhan Wu ,Xizhou Zhu ,Susanne N Walker ,Ziyang Xu ,Katherine Schultheis ,Neethu Chokkalingam ,Himanshi Chawla ,Jianqiu Du ,Nicholas J Tursi ,Alan Moore ,Jared Adolf-Bryfogle ,Mansi Purwar ,Emma L Reuschel ,Drew Frase ,Matthew Sullivan ,Benjamin Fry ,Igor Maricic ,Viviane M Andrade ,Christel Iffland ,Max Crispin ,Kate E Broderick ,Laurent M P F Humeau ,Ami Patel ,Trevor R F Smith ,Jesper Pallesen ,David B Weiner ,Daniel W Kulp

Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants

对所有相关 SARS-CoV-2 变体具有皮摩尔结合亲和力的中和抗体的计算设计

Bo-Seong Jeong, Jeong Seok Cha, Insu Hwang, Uijin Kim, Jared Adolf-Bryfogle, Brian Coventry, Hyun-Soo Cho, Kyun-Do Kim, Byung-Ha Oh

Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia

伯克霍尔德菌两种 cif 样环氧化物水解酶的生化和结构表征

Noor M Taher, Kelli L Hvorecny, Cassandra M Burke, Morgan S A Gilman, Gary E Heussler, Jared Adolf-Bryfogle, Christopher D Bahl, George A O'Toole, Dean R Madden

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design

RosettaAntibodyDesign (RAbD):计算抗体设计的通用框架

Jared Adolf-Bryfogle, Oleks Kalyuzhniy, Michael Kubitz, Brian D Weitzner, Xiaozhen Hu, Yumiko Adachi, William R Schief, Roland L Dunbrack Jr

Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation

激酶介导的核小体构象变化通过聚(ADP-核糖基化)引发染色质解聚

Colin J Thomas, Elena Kotova, Mark Andrake, Jared Adolf-Bryfogle, Robert Glaser, Catherine Regnard, Alexei V Tulin