Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus
通过使用 RosettaAntibodyDesign (RAbD) 设计抗体 80R 的特异性开关,计算设计针对多种 SARS-CoV-2 变体的纳摩尔结合抗体,从而为新型 SARS-CoV-2 病毒提供潜在的可推广治疗性抗体
期刊:Heliyon
影响因子:3.4
doi:10.1016/j.heliyon.2023.e15032
Nancy E Hernandez, Wojciech Jankowski, Rahel Frick, Simon P Kelow, Joseph H Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D Khare, Roland L Dunbrack Jr, Jeffrey J Gray, Zuben E Sauna