日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

口服核苷类似物奥贝地西韦对非洲绿猴的呼吸道合胞病毒感染有效。

Jared Pitts #,J Lizbeth Reyes Zamora #,Savrina Manhas,Thomas Aeschbacher,Josolyn Chan,Vincent Cutillas,Varsha Nair,Nicholas C Riola,Arya Vijjapurapu,Meghan S Vermillion,Stacey Eng,Christopher Richards,Dong Han,Jason K Perry,Subhra Chaudhuri,Szu-Wen Liu,Clarissa Martinez,Nadine Peinovich,Kai-Hui Sun,Arthur Cai,Ross Martin,Jasmine Moshiri,Charlotte Hedskog,Darius Babusis,Dustin S Siegel,Rao Kalla,Vasanthi Avadhanula,Pedro A Piedra,Kim Stobbelaar,Peter L Delputte,Caleb Marceau,Roberto Mateo,Evguenia Maiorova,Hongmei Mo,Raju Subramanian,Richard L Mackman,Tomas Cihlar,Simon P Fletcher,John P Bilello

Structure of anellovirus-like particles reveal a mechanism for immune evasion

类指病毒颗粒的结构揭示了免疫逃避机制

Shu-Hao Liou #, Rajendra Boggavarapu #, Noah R Cohen, Yue Zhang, Ishwari Sharma, Lynn Zeheb, Nidhi Mukund Acharekar, Hillary D Rodgers, Saadman Islam, Jared Pitts, Cesar Arze, Harish Swaminathan, Nathan Yozwiak, Tuyen Ong, Roger J Hajjar, Yong Chang, Kurt A Swanson, Simon Delagrave

Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

4'-氰基修饰核苷酸类似物对原型呼吸道 RNA 病毒不同 RNA 聚合酶的抑制机制和抑制谱

Calvin J Gordon, Simon M Walker, Egor P Tchesnokov, Dana Kocincova, Jared Pitts, Dustin S Siegel, Jason K Perry, Joy Y Feng, John P Bilello, Matthias Götte

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

发现 GS-5245(奥贝地西韦),这是核苷 GS-441524 的口服前药,对感染 SARS-CoV-2 的非洲绿猴具有抗病毒功效

Richard L Mackman, Rao V Kalla, Darius Babusis, Jared Pitts, Kimberly T Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B Michael O'Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Kassibla Elodie Dempah, Elaine Bunya

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

吸入瑞德西韦可减轻非人类灵长类动物 SARS-CoV-2 感染模型中的病毒负担

Meghan S Vermillion, Eisuke Murakami, Bin Ma, Jared Pitts, Adrian Tomkinson, Davin Rautiola, Darius Babusis, Hammad Irshad, Dustin Seigel, Cynthia Kim, Xiaofeng Zhao, Congrong Niu, Jesse Yang, Andrew Gigliotti, Nani Kadrichu, John P Bilello, Scott Ellis, Roy Bannister, Raju Subramanian, Bill Smith, 

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

瑞德西韦和 GS-441524 保留了对 Delta、Omicron 和其他新出现的 SARS-CoV-2 变体的抗病毒活性

Jared Pitts, Jiani Li, Jason K Perry, Venice Du Pont, Nicholas Riola, Lauren Rodriguez, Xianghan Lu, Chaitanya Kurhade, Xuping Xie, Gregory Camus, Savrina Manhas, Ross Martin, Pei-Yong Shi, Tomas Cihlar, Danielle P Porter, Hongmei Mo, Evguenia Maiorova, John P Bilello

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

参与瑞德西韦在人肺细胞中激活的关键代谢酶

Ruidong Li #, Albert Liclican #, Yili Xu, Jared Pitts, Congrong Niu, Jingyu Zhang, Cynthia Kim, Xiaofeng Zhao, Daniel Soohoo, Darius Babusis, Qin Yue, Bin Ma, Bernard P Murray, Raju Subramanian, Xuping Xie, Jing Zou, John P Bilello, Li Li, Brian E Schultz, Roman Sakowicz, Bill J Smith, Pei-Yong Shi,