Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
小鼠复合体A鞭毛内转运基因Ift122/Wdr10失活,导致纤毛发生缺陷、胚胎致死和Sonic Hedgehog信号通路严重受损,该基因与DNA修复基因Med1/Mbd4部分重叠。
期刊:Developmental Biology
影响因子:2.1
doi:10.1016/j.ydbio.2008.10.020
Cortellino, Salvatore; Wang, Chengbing; Wang, Baolin; Bassi, Maria Rosaria; Caretti, Elena; Champeval, Delphine; Calmont, Amelie; Jarnik, Michal; Burch, John; Zaret, Kenneth S; Larue, Lionel; Bellacosa, Alfonso