日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Direct-to-Biology Enabled Molecular Glue Discovery

直接应用于生物学领域的分子胶发现

Hu, Maowei; Ochoada, Jason; Actis, Marisa; McGowan, Kevin; Jarusiewicz, Jamie A; Yoshimura, Satoshi; McGrath, Logan; Neelakantan, Uma; Aggarwal, Anup; Mayasundari, Anand; Young, Sarah M; Zhang, Meng; Yang, Lei; Li, Yong; Mercer, Shea; Babu, M Madan; Fischer, Marcus; Young, Brandon M; Yang, Jun J; Nishiguchi, Gisele; Shelat, Anang A; Blair, Daniel J

LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia

靶向LCK的分子胶克服了T细胞急性淋巴细胞白血病对抑制剂疗法的耐药性

Yang, Jun J; Nishiguchi, Gisele; Yoshimura, Satoshi; Actis, Marisa; Seffernick, Justin T; Jarusiewicz, Jamie A; Aggarwal, Anup; Li, Angelina; Li, Yong; Lee, DongGeun; Yang, Lei; Mayasundari, Anand; Rankovic, Zoran; Fischer, Marcus

Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia

蛋白水解靶向 LCK 作为 T 细胞急性淋巴细胞白血病治疗方法的临床前评估

Jianzhong Hu, Jamie Jarusiewicz, Guoqing Du, Gisele Nishiguchi, Satoshi Yoshimura, John C Panetta, Zhenhua Li, Jaeki Min, Lei Yang, Divyabharathi Chepyala, Marisa Actis, Noemi Reyes, Brandon Smart, Ching-Hon Pui, David T Teachey, Zoran Rankovic, Jun J Yang

Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs

开发有效且选择性的 Janus Kinase 2/3 指导 PG-PROTAC

Lisa J Alcock, Yunchao Chang, Jamie A Jarusiewicz, Marisa Actis, Stanley Nithianantham, Anand Mayasundari, Jaeki Min, Dylan Maxwell, Jeremy Hunt, Brandon Smart, Jun J Yang, Gisele Nishiguchi, Marcus Fischer, Charles G Mullighan, Zoran Rankovic

Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia

CRLF2 重排急性淋巴细胞白血病中 Janus 激酶的降解

Yunchao Chang, Jaeki Min, Jamie A Jarusiewicz, Marisa Actis, Shanshan Yu-Chen Bradford, Anand Mayasundari, Lei Yang, Divyabharathi Chepyala, Lisa J Alcock, Kathryn G Roberts, Stanley Nithianantham, Dylan Maxwell, Lauren Rowland, Randolph Larsen, Aman Seth, Hiroaki Goto, Toshihiko Imamura, Koshi Akah

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

从聚焦的 Cereblon 调节剂库中鉴定高效、选择性强且口服生物利用度高的小分子 GSPT1/2 降解剂

Gisele Nishiguchi,Fatemeh Keramatnia,Jaeki Min,Yunchao Chang,Barbara Jonchere,Sourav Das,Marisa Actis,Jeanine Price,Divyabharathi Chepyala,Brandon Young,Kevin McGowan,P Jake Slavish,Anand Mayasundari,Jamie A Jarusiewicz,Lei Yang,Yong Li,Xiang Fu,Shalandus H Garrett,James B Papizan,Kiran Kodali,Junmin Peng,Shondra M Pruett Miller,Martine F Roussel,Charles Mullighan,Marcus Fischer,Zoran Rankovic

Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

苯基戊二酰亚胺:用于 PROTAC 设计的替代 Cereblon 粘合剂

Jaeki Min, Anand Mayasundari, Fatemeh Keramatnia, Barbara Jonchere, Seung Wook Yang, Jamie Jarusiewicz, Marisa Actis, Sourav Das, Brandon Young, Jake Slavish, Lei Yang, Yong Li, Xiang Fu, Shalandus H Garrett, Mi-Kyung Yun, Zhenmei Li, Stanley Nithianantham, Sergio Chai, Taosheng Chen, Anang Shelat, 

Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus

通过一种抑制耐甲氧西林金黄色葡萄球菌中 vraTSR 表达的新型检测方法鉴定表现出苯唑西林协同作用的小分子

Hyun Lee, Susan Boyle-Vavra, Jinhong Ren, Jamie A Jarusiewicz, Lalit Kumar Sharma, Daniel T Hoagland, Shaohui Yin, Tian Zhu, Kirk E Hevener, Isabel Ojeda, Richard E Lee, Robert S Daum, Michael E Johnson

Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia

发现一种对急性髓系白血病有效的二氨基嘧啶 FLT3 抑制剂

Jamie A Jarusiewicz, Jae Yoon Jeon, Michele C Connelly, Yizhe Chen, Lei Yang, Sharyn D Baker, R Kiplin Guy

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2

通过阻断 IIa 类 HDAC 与 MEF2 的相互作用来抑制其功能

Nimanthi Jayathilaka, Aidong Han, Kevin J Gaffney, Raja Dey, Jamie A Jarusiewicz, Kaori Noridomi, Michael A Philips, Xiao Lei, Ju He, Jun Ye, Tao Gao, Nicos A Petasis, Lin Chen