日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

DNA低甲基化使早期前列腺癌和循环肿瘤细胞中的抗肿瘤免疫基因沉默

Hongshan Guo ,Joanna A Vuille ,Ben S Wittner ,Emily M Lachtara ,Yu Hou ,Maoxuan Lin ,Ting Zhao ,Ayush T Raman ,Hunter C Russell ,Brittany A Reeves ,Haley M Pleskow ,Chin-Lee Wu ,Andreas Gnirke ,Alexander Meissner ,Jason A Efstathiou ,Richard J Lee ,Mehmet Toner ,Martin J Aryee ,Michael S Lawrence ,David T Miyamoto ,Shyamala Maheswaran ,Daniel A Haber

An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer

基于 RNA 的数字循环肿瘤细胞特征可预测前列腺癌的药物反应和早期扩散

David T Miyamoto #, Richard J Lee #, Mark Kalinich, Joseph A LiCausi, Yu Zheng, Tianqi Chen, John D Milner, Erin Emmons, Uyen Ho, Katherine Broderick, Erin Silva, Sarah Javaid, Tanya Todorova Kwan, Xin Hong, Douglas M Dahl, Francis J McGovern, Jason A Efstathiou, Matthew R Smith, Lecia V Sequist, Ra

PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53

无论是否使用电离辐射,PARP-1 抑制都会优先对具有突变 TP53 的癌细胞产生活性氧介导的细胞毒性

Qi Liu, Liliana Gheorghiu, Michael Drumm, Rebecca Clayman, Alec Eidelman, Matthew F Wszolek, Aria Olumi, Adam Feldman, Meng Wang, Lynnette Marcar, Deborah E Citrin, Chin-Lee Wu, Cyril H Benes, Jason A Efstathiou, Henning Willers

Adapting a drug screening platform to discover associations of molecular targeted radiosensitizers with genomic biomarkers

调整药物筛选平台以发现分子靶向放射增敏剂与基因组生物标志物的关联

Qi Liu, Meng Wang, Ashley M Kern, Saman Khaled, Jing Han, Beow Y Yeap, Theodore S Hong, Jeff Settleman, Cyril H Benes, Kathryn D Held, Jason A Efstathiou, Henning Willers

EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation

EGFR 介导的染色质凝聚保护 KRAS 突变癌细胞免受电离辐射

Meng Wang, Ashley M Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H Benes, Jason A Efstathiou, Jeff Settleman, Henning Willers