日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Nathalie Khoury,Michelle E Pizzo,Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha,Gabrielly L De Melo,Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie S Chew,Johann Chow,Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker,Holly Kane,Amy Leung,Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk,Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model

在早期发育过程中,血脑屏障处转铁蛋白受体介导的转运水平升高,并在衰老过程中以及阿尔茨海默病小鼠模型中维持稳定。

Vanessa O Torres ,Michelle E Pizzo ,Darren Chan ,Jason C Dugas ,David Huynh ,David Joy ,Eric K Liang ,Lily Sarrafha ,Isabel Becerra ,Roni Chau ,Kylie S Chew ,Johann Chow ,Claire B Discenza ,Timothy K Earr ,Laura Furaso ,Nathalie Khoury ,Kendra J Lechtenberg ,Amy W Leung ,Hoang N Nguyen ,Emmanuel S Ojo ,Elysia Roche ,Matthew J Simon ,Hilda Solanoy ,Mabel Tong ,Raymond K Tong ,Kirk Henne ,Joseph W Lewcock ,Ryan J Watts ,Meredith E Calvert ,Robert G Thorne ,Y Joy Yu Zuchero

SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons

SARM1 负责小鼠海马神经元中钙蛋白酶依赖性树突变性

Takashi Miyamoto, Chaeyoung Kim, Johann Chow, Jason C Dugas, Jack DeGroot, Alex L Bagdasarian, Arun P Thottumkara, Martin Larhammar, Meredith Ek Calvert, Brian M Fox, Joseph W Lewcock, Lesley A Kane

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

一种带有血脑屏障转运载体的TREM2激活抗体可增强阿尔茨海默病模型中的小胶质细胞代谢。

Bettina van Lengerich # ,Lihong Zhan # ,Dan Xia # ,Darren Chan ,David Joy ,Joshua I Park ,David Tatarakis ,Meredith Calvert ,Selina Hummel ,Steve Lianoglou ,Michelle E Pizzo ,Rachel Prorok ,Elliot Thomsen ,Laura M Bartos ,Philipp Beumers ,Anja Capell ,Sonnet S Davis ,Lis de Weerd ,Jason C Dugas ,Joseph Duque ,Timothy Earr ,Kapil Gadkar ,Tina Giese ,Audrey Gill ,Johannes Gnörich ,Connie Ha ,Malavika Kannuswamy ,Do Jin Kim ,Sebastian T Kunte ,Lea H Kunze ,Diana Lac ,Kendra Lechtenberg ,Amy Wing-Sze Leung ,Chun-Chi Liang ,Isabel Lopez ,Paul McQuade ,Anuja Modi ,Vanessa O Torres ,Hoang N Nguyen ,Ida Pesämaa ,Nicholas Propson ,Marvin Reich ,Yaneth Robles-Colmenares ,Kai Schlepckow ,Luna Slemann ,Hilda Solanoy ,Jung H Suh ,Robert G Thorne ,Chandler Vieira ,Karin Wind-Mark ,Ken Xiong ,Y Joy Yu Zuchero ,Dolo Diaz ,Mark S Dennis ,Fen Huang ,Kimberly Scearce-Levie ,Ryan J Watts ,Christian Haass ,Joseph W Lewcock ,Gilbert Di Paolo ,Matthias Brendel ,Pascal E Sanchez ,Kathryn M Monroe

Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme

分子结构决定了转铁蛋白受体靶向溶酶体酶的大脑输送

Annie Arguello #, Cathal S Mahon #, Meredith E K Calvert, Darren Chan, Jason C Dugas, Michelle E Pizzo, Elliot R Thomsen, Roni Chau, Lorna A Damo, Joseph Duque, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, Hoang N Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, Julie C Ullman, Junhua Wang, Ma

Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome

艾杜糖醛酸-2-硫酸酯酶转运载体挽救亨特综合征小鼠模型中的行为和骨骼表型

Annie Arguello, René Meisner, Elliot R Thomsen, Hoang N Nguyen, Ritesh Ravi, Jeffrey Simms, Iris Lo, Jessica Speckart, Julia Holtzman, Thomas M Gill, Darren Chan, Yuhsiang Cheng, Chi-Lu Chiu, Jason C Dugas, Meng Fang, Isabel A Lopez, Hilda Solanoy, Buyankhishig Tsogtbaatar, Yuda Zhu, Akhil Bhalla, K

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

TREM2 在慢性吞噬挑战下调节小胶质细胞胆固醇代谢

Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C G Haddick, Melina Lenser, Timothy K Earr, Ju Shi, Jason C Dugas, Benjamin J Andreone, Todd Log

Longitudinal biomarkers in amyotrophic lateral sclerosis

肌萎缩侧索硬化症的纵向生物标志物

Fen Huang, Yuda Zhu, Jennifer Hsiao-Nakamoto, Xinyan Tang, Jason C Dugas, Miriam Moscovitch-Lopatin, Jonathan D Glass, Robert H Brown Jr, Shafeeq S Ladha, David Lacomis, Jeffrey M Harris, Kimberly Scearce-Levie, Carole Ho, Robert Bowser, James D Berry

High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II

利用高通量液相色谱-串联质谱法定量分析糖胺聚糖作为粘多糖贮积症II型的生物标志物

Junhua Wang ,Akhil Bhalla ,Julie C Ullman ,Meng Fang ,Ritesh Ravi ,Annie Arguello ,Elliot Thomsen ,Buyankhishig Tsogtbaatar ,Jing L Guo ,Lukas L Skuja ,Jason C Dugas ,Sonnet S Davis ,Suresh B Poda ,Kannan Gunasekaran ,Simona Costanzo ,Zachary K Sweeney ,Anastasia G Henry ,Jeffrey M Harris ,Kirk R Henne ,Giuseppe Astarita