日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Draft genome of Bugula neritina, a colonial animal packing powerful symbionts and potential medicines

Bugula neritina 的基因组草图,这是一种群居动物,体内含有强大的共生体和潜在的药物成分。

Rayko, Mikhail; Komissarov, Aleksey; Kwan, Jason C; Lim-Fong, Grace; Rhodes, Adelaide C; Kliver, Sergey; Kuchur, Polina; O'Brien, Stephen J; Lopez, Jose V

CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes

CALHM3 对 GPCR 介导的味觉快速离子通道介导的嘌呤能神经传递至关重要

Zhongming Ma, Akiyuki Taruno, Makoto Ohmoto, Masafumi Jyotaki, Jason C Lim, Hiroaki Miyazaki, Naomi Niisato, Yoshinori Marunaka, Robert J Lee, Henry Hoff, Riley Payne, Angelo Demuro, Ian Parker, Claire H Mitchell, Jorge Henao-Mejia, Jessica E Tanis, Ichiro Matsumoto, Michael G Tordoff, J Kevin Foske

The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration

P2Y12 受体拮抗剂替格瑞洛可降低 ABCA4-/- 视网膜变性小鼠模型中视网膜色素上皮细胞的溶酶体 pH 值和自发荧光

Wennan Lu, Néstor M Gómez, Jason C Lim, Sonia Guha, Ann O'Brien-Jenkins, Erin E Coffey, Keith E Campagno, Stuart A McCaughey, Alan M Laties, Leif G Carlsson, Claire H Mitchell

Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation

溶酶体脂质积累削弱了通过通道 TRPML1 进行的强溶酶体钙信号传导

Néstor Más Gómez, Wennan Lu, Jason C Lim, Kirill Kiselyov, Keith E Campagno, Yulia Grishchuk, Susan A Slaugenhaupt, Bruce A Pfeffer, Steven J Fliesler, Claire H Mitchell

Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels

TLR3 的刺激会触发星形胶质细胞和上皮细胞中溶酶体 ATP 的释放,而这需要 TRPML1 通道

Jonathan M Beckel, Néstor Más Gómez, Wennan Lu, Keith E Campagno, Bardia Nabet, Farraj Albalawi, Jason C Lim, Kathleen Boesze-Battaglia, Claire H Mitchell

Effects of Lidocaine and Articaine on Neuronal Survival and Recovery

利多卡因和阿替卡因对神经元存活和恢复的影响

Farraj Albalawi, Jason C Lim, Kyle V DiRenzo, Elliot V Hersh, Claire H Mitchell

The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes

P2X7 受体将机械应变与神经元和星形胶质细胞中的细胞因子 IL-6 上调和释放联系起来

Wennan Lu, Farraj Albalawi, Jonathan M Beckel, Jason C Lim, Alan M Laties, Claire H Mitchell

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

P2X7 受体在受到机械应变的星形胶质细胞中引发 IL-1β 和 NLRP3 炎症小体

Farraj Albalawi, Wennan Lu, Jonathan M Beckel, Jason C Lim, Stuart A McCaughey, Claire H Mitchell

Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective

P2X7 受体的机械敏感性自刺激引发的细胞因子 IL-3 的神经元释放具有神经保护作用

Jason C Lim, Wennan Lu, Jonathan M Beckel, Claire H Mitchell

Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain

通过 Pannexin 通道机械敏感地释放 5'-三磷酸腺苷以及视神经头部星形胶质细胞中 Pannexin 通道机械敏感地上调:嘌呤能参与慢性劳损的机制

Jonathan M Beckel, Arthur J Argall, Jason C Lim, Jingsheng Xia, Wennan Lu, Erin E Coffey, Edward J Macarak, Mohammed Shahidullah, Nicholas A Delamere, Gulab S Zode, Val C Sheffield, Valery I Shestopalov, Alan M Laties, Claire H Mitchell