Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR
KRAS 突变结直肠癌模型中，对激酶 PI3K 和 mTOR 双重阻断的抵抗导致对受体酪氨酸激酶 EGFR 抑制的综合敏感性
期刊:Science Signaling
影响因子:
doi:10.1126/scisignal.2005516
Peter J Belmont, Ping Jiang, Trevor D McKee, Tao Xie, Jason Isaacson, Nicole E Baryla, Jatin Roper, Mark J Sinnamon, Nathan V Lee, Julie L C Kan, Oivin Guicherit, Bradly G Wouters, Catherine A O'Brien, David Shields, Peter Olson, Todd VanArsdale, Scott L Weinrich, Paul Rejto, James G Christensen, Va
