日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Suppression of thrombospondin-1-mediated inflammaging prolongs hematopoietic health span

抑制血小板反应蛋白-1介导的炎症衰老可延长造血系统健康寿命。

Pradeep Ramalingam,Michael C Gutkin,Michael G Poulos,Agatha Winiarski,Arianna Smith,Cody Carter,Chelsea Doughty,Taylor Tillery,David Redmond,Ana G Freire,Jason M Butler

CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow

CCR2协同作用促进造血干细胞归巢至骨髓

Stephanie N Hurwitz ,Danielle R Kobulsky ,Seul K Jung ,Jennifer J Chia ,Jason M Butler ,Peter Kurre

Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow

用于评估骨髓内皮细胞亚型功能的互补和可诱导的 creERT2 小鼠模型

Michael G Poulos, Pradeep Ramalingam, Agatha Winiarski, Michael C Gutkin, Lizabeth Katsnelson, Cody Carter, Laurence Pibouin-Fragner, Anne Eichmann, Jean-Leon Thomas, Lucile Miquerol, Jason M Butler

Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response

恢复骨髓微环境功能可通过重新激活DNA损伤反应来使衰老的造血干细胞恢复活力。

Pradeep Ramalingam # ,Michael C Gutkin # ,Michael G Poulos # ,Taylor Tillery ,Chelsea Doughty ,Agatha Winiarski ,Ana G Freire ,Shahin Rafii ,David Redmond ,Jason M Butler

Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics

利用整合的单细胞转录组学设计支持造血干细胞发育的微环境

Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M Heck, Takashi Ishida, Dana L Jackson, Tomer Itkin, Jason M Butler, Shahin Rafii, Cole Trapnell, Irwin D Bernstein

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

内皮细胞MAPK的慢性激活通过NF-κB依赖性炎症应激破坏造血功能,而SCGF可逆转这种炎症应激。

Pradeep Ramalingam ,Michael G Poulos ,Elisa Lazzari ,Michael C Gutkin ,David Lopez ,Christopher C Kloss ,Michael J Crowley ,Lizabeth Katsnelson ,Ana G Freire ,Matthew B Greenblatt ,Christopher Y Park ,Jason M Butler

Endothelial mTOR maintains hematopoiesis during aging

内皮细胞 mTOR 在衰老过程中维持造血功能

Pradeep Ramalingam ,Michael G Poulos ,Michael C Gutkin ,Lizabeth Katsnelson ,Ana G Freire ,Elisa Lazzari ,Jason M Butler

Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model

抑制氧化磷酸化可逆转可成像同基因 B-ALL 小鼠模型中观察到的骨髓缺氧

Mateusz Rytelewski, Karine Harutyunyan, Natalia Baran, Saradhi Mallampati, M Anna Zal, Antonio Cavazos, Jason M Butler, Sergej Konoplev, Mirna El Khatib, Shane Plunkett, Joseph R Marszalek, Michael Andreeff, Tomasz Zal, Marina Konopleva

The bone marrow microenvironment at single-cell resolution

单细胞分辨率下的骨髓微环境

Anastasia N Tikhonova #,Igor Dolgalev #,Hai Hu,Kishor K Sivaraj,Edlira Hoxha,Álvaro Cuesta-Domínguez,Sandra Pinho,Ilseyar Akhmetzyanova,Jie Gao,Matthew Witkowski,Maria Guillamot,Michael C Gutkin,Yutong Zhang,Christian Marier,Catherine Diefenbach,Stavroula Kousteni,Adriana Heguy,Hua Zhong,David R Fooksman,Jason M Butler,Aris Economides,Paul S Frenette,Ralf H Adams,Rahul Satija,Aristotelis Tsirigos,Iannis Aifantis

Targeting skeletal endothelium to ameliorate bone loss

靶向骨骼内皮以改善骨质流失

Ren Xu ,Alisha Yallowitz ,An Qin ,Zhuhao Wu ,Dong Yeon Shin ,Jung-Min Kim ,Shawon Debnath ,Gang Ji ,Mathias P Bostrom ,Xu Yang ,Chao Zhang ,Han Dong ,Pouneh Kermani ,Sarfaraz Lalani ,Na Li ,Yifang Liu ,Michael G Poulos ,Amanda Wach ,Yi Zhang ,Kazuki Inoue ,Annarita Di Lorenzo ,Baohong Zhao ,Jason M Butler ,Jae-Hyuck Shim ,Laurie H Glimcher ,Matthew B Greenblatt