日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule-RNA binding events in native cells

光亲和技术能够对天然细胞中调控剪接的小分子-RNA结合事件进行全转录组范围的鉴定。

Raven Shah,Wanlin Yan,Joyce Rigal,Steve Mullin,Lin Fan,Lynn McGregor,Andrew Krueger,Nicole Renaud,Andrea Byrnes,Jason R Thomas

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

基于 DCAF1 的 PROTAC 具有针对临床验证靶标的活性,可克服内在和获得性降解剂耐药性

Martin Schröder #, Martin Renatus #, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pi

Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter─Compounds with Novel Mechanisms from High-Throughput Screening Profiles

利用灰色化学物质增强已知化学基因组学库之外的小规模可筛选生物空间─从高通量筛选概况中筛选出具有新机制的化合物

Jason R Thomas, Claude Shelton 4th, Jason Murphy, Scott Brittain, Mark-Anthony Bray, Peter Aspesi, John Concannon, Frederick J King, Robert J Ihry, Daniel J Ho, Martin Henault, Andrea Hadjikyriacou, Marilisa Neri, Frederic D Sigoillot, Helen T Pham, Matthew Shum, Louise Barys, Michael D Jones, Eric

PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer

PHY34 通过抑制 V-ATPase V0A2 亚基和 CAS/CSE1L 核货物运输来抑制高级别浆液性卵巢癌中的自噬

Amrita Salvi #, Alexandria N Young #, Andrew C Huntsman, Melissa R Pergande, Melissa A Korkmaz, Rathnayake A Rathnayake, Brittney K Mize, A Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R Thomas, Scott M Brittain, Claude Shelton, Leslie N Aldrich, Stephanie M Cologna, James R Fu

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma

CPSF3依赖性前体mRNA加工是急性髓系白血病和尤文氏肉瘤中可作为药物靶点的节点

Nathan T Ross # ,Felix Lohmann # ,Seth Carbonneau ,Aleem Fazal ,Wilhelm A Weihofen ,Scott Gleim ,Michael Salcius ,Frederic Sigoillot ,Martin Henault ,Sarah H Carl ,Juan B Rodríguez-Molina ,Howard R Miller ,Scott M Brittain ,Jason Murphy ,Mark Zambrowski ,Geoffrey Boynton ,Yuan Wang ,Aye Chen ,Gregory J Molind ,Johannes H Wilbertz ,Caroline G Artus-Revel ,Min Jia ,Favour A Akinjiyan ,Jonathan Turner ,Judith Knehr ,Walter Carbone ,Sven Schuierer ,John S Reece-Hoyes ,Kevin Xie ,Chitra Saran ,Eric T Williams ,Guglielmo Roma ,Matt Spencer ,Jeremy Jenkins ,Elizabeth L George ,Jason R Thomas ,Gregory Michaud ,Markus Schirle ,John Tallarico ,Lori A Passmore ,Jeffrey A Chao ,Rohan E J Beckwith #

Discovery of a ZIP7 inhibitor from a Notch pathway screen

通过 Notch 通路筛选发现 ZIP7 抑制剂

Erin Nolin, Sara Gans, Luis Llamas, Somnath Bandyopadhyay, Scott M Brittain, Paula Bernasconi-Elias, Kyle P Carter, Joseph J Loureiro, Jason R Thomas, Markus Schirle, Yi Yang, Ning Guo, Guglielmo Roma, Sven Schuierer, Martin Beibel, Alicia Lindeman, Frederic Sigoillot, Amy Chen, Kevin X Xie, Samuel

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

利用抗癌天然产物印楝内酯进行靶向蛋白质降解

Jessica N Spradlin, Xirui Hu, Carl C Ward, Scott M Brittain, Michael D Jones, Lisha Ou, Milton To, Andrew Proudfoot, Elizabeth Ornelas, Mikias Woldegiorgis, James A Olzmann, Dirksen E Bussiere, Jason R Thomas, John A Tallarico, Jeffrey M McKenna, Markus Schirle, Thomas J Maimone, Daniel K Nomura

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

共价配体筛选揭示 RNF4 E3 连接酶募集剂,可用于靶向蛋白质降解应用

Carl C Ward, Jordan I Kleinman, Scott M Brittain, Patrick S Lee, Clive Yik Sham Chung, Kenneth Kim, Yana Petri, Jason R Thomas, John A Tallarico, Jeffrey M McKenna, Markus Schirle, Daniel K Nomura

A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling

巨噬细胞中的高内涵筛选可鉴定出 STING-IRF3 和 NFkB 信号的小分子调节剂

Peter D Koch, Howard R Miller, Gary Yu, John A Tallarico, Peter K Sorger, Yuan Wang, Yan Feng, Jason R Thomas, Nathan T Ross, Timothy Mitchison

Nitric oxide and cancer therapy: the emperor has NO clothes

一氧化氮与癌症治疗:皇帝的新衣

Hickok, Jason R; Thomas, Douglas D