日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon

CRISPR 筛选通过丝氨酸甘氨酸一碳识别胆管癌中的 BET 和 mTOR 抑制剂协同作用

Yan Zhu, Dengyong Zhang, Pooja Shukla, Young-Ho Jung, Prit Benny Malgulwar, Sharmeen Chagani, Medina Colic, Sarah Benjamin, John A Copland 3rd, Lin Tan, Philip L Lorenzi, Milind Javle, Jason T Huse, Jason Roszik, Traver Hart, Lawrence N Kwong

Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor-positive Breast Cancer

雌激素受体突变作为转移性雌激素受体阳性乳腺癌免疫治疗的新靶点

Jonathan Goldberg #, Na Qiao #, Jennifer L Guerriero, Brett Gross, Yagiz Meneksedag, Yoshimi F Lu, Anne V Philips, Tasnim Rahman, Funda Meric-Bernstam, Jason Roszik, Ken Chen, Rinath Jeselsohn, Sara M Tolaney, George E Peoples, Gheath Alatrash #, Elizabeth A Mittendorf #

Novel murine glioblastoma models that reflect the immunotherapy resistance profile of a human disease

反映人类疾病免疫疗法抵抗特征的新型鼠胶质母细胞瘤模型

Chao-Hsien Chen, Renee L Chin, Genevieve P Hartley, Spencer T Lea, Brian J Engel, Cheng-En Hsieh, Rishika Prasad, Jason Roszik, Takashi Shingu, Gregory A Lizee, Amy B Heimberger, Steven W Millward, Jian Hu, David S Hong, Michael A Curran

Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer

长春新碱可增强MEK抑制剂在KRAS突变型结直肠癌临床前模型中的疗效

Susmita Ghosh ,Fan Fan ,Reid T Powell ,Jason Roszik ,Yong Sung Park ,Clifford Stephan ,Manu Sebastian ,Lin Tan ,Alexey V Sorokin ,Philip L Lorenzi ,Scott Kopetz ,Lee M Ellis ,Rajat Bhattacharya

Loss of AMPKα2 promotes melanoma tumor growth and brain metastasis

AMPKα2的缺失促进黑色素瘤的生长和脑转移

Ping Yuan, Da Teng, Evelyn de Groot, Man Li, Sebastian Trousil, Che-Hung Shen, Jason Roszik, Michael A Davies, Y N Vashisht Gopal, Bin Zheng

Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo

联合使用 MEK 和 SRC 抑制剂治疗结直肠癌在体外表现出疗效增强,但在体内没有表现出疗效

Fan Fan, Susmita Ghosh, Reid Powell, Jason Roszik, Yongsun Park, Mary Sobieski, Alexey Sorokin, Clifford Stephan, Scott Kopetz, Lee M Ellis, Rajat Bhattacharya

Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion

抑制微粒体前列腺素 E2 合酶可减少黑色素瘤中的胶原沉积,并可能通过减少 T 细胞耗竭来提高免疫治疗效果

Yasunari Fukuda, Sun-Hee Kim, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Jared K Burks, Hong Kim, Dave S B Hoon, Elizabeth A Grimm, Suhendan Ekmekcioglu

Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma

Rnf43 的缺失加速了 Kras 介导的肿瘤形成并重塑了胰腺腺癌中的肿瘤免疫微环境

Abdel Nasser Hosein, Gita Dangol, Takashi Okumura, Jason Roszik, Kimal Rajapakshe, Megan Siemann, Mohamed Zaid, Bidyut Ghosh, Maria Monberg, Paola A Guerrero, Aatur Singhi, Cara L Haymaker, Hans Clevers, Lotfi Abou-Elkacem, Sonja M Woermann, Anirban Maitra

Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102

滑膜肉瘤中苹果酸酶 1 的缺失会改变抗氧化系统依赖性并增加对 ACXT-3102 诱导铁死亡的敏感性

Caitlyn B Brashears #, Bethany C Prudner #, Richa Rathore, Katharine E Caldwell, Carina A Dehner, Jane L Buchanan, Sara E S Lange, Neal Poulin, Jennifer K Sehn, Jason Roszik, Dirk Spitzer, Kevin B Jones, Regis O'Keefe, Torsten O Nielsen, Eric B Taylor, Jason M Held, William Hawkins, Brian A Van Tine

Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma

可溶性 CD74 与巨噬细胞迁移抑制因子之间的相互作用促进肿瘤生长并影响黑色素瘤患者的生存

Yasunari Fukuda, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M Lopez, Jared K Burks, Jeffrey E Lee, Elizabeth A Grimm, Dave S B Hoon, Suhendan Ekmekcioglu