日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting chromosomally unstable tumors with a selective KIF18A inhibitor

利用选择性KIF18A抑制剂靶向治疗染色体不稳定的肿瘤

Aaron F Phillips,Rumin Zhang,Mia Jaffe,Ryan Schulz,Marysol Chu Carty,Akanksha Verma,Tamar Y Feinberg,Michael D Arensman,Alan Chiu,Reka Letso,Nazario Bosco,Katelyn A Queen,Allison R Racela,Jason Stumpff,Celia Andreu-Agullo,Sarah E Bettigole,Rafael S Depetris,Scott Drutman,Shinsan M Su,Derek A Cogan,Christina H Eng

The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis

组蛋白H3.3 K27M突变抑制Ser31磷酸化和有丝分裂保真度,这可直接驱动胶质瘤的发生。

Charles A Day ,Florina Grigore ,Faruck L Hakkim ,Souren Paul ,Alyssa Langfald ,Molly Weberg ,Sela Fadness ,Paiton Schwab ,Leslie Sepaniac ,Jason Stumpff ,Kevin T Vaughan ,David J Daniels ,James P Robinson ,Edward H Hinchcliffe

Modification of the neck-linker of KIF18A alters Microtubule subpopulation preference

KIF18A颈部连接器的修饰改变了微管亚群的偏好

Katelyn A Queen, Alisa Cario, Christopher L Berger, Jason Stumpff

Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression

Anapc5 和 Anapc7 作为 KIF18A 的遗传修饰因子在生育力和有丝分裂进程中发挥作用

Carleigh Nesbit, Whitney Martin, Anne Czechanski, Candice Byers, Narayanan Raghupathy, Ardian Ferraj, Jason Stumpff, Laura Reinholdt

Modification of the Neck Linker of KIF18A Alters Microtubule Subpopulation Preference

KIF18A 颈部连接子的修饰改变了微管亚群的偏好

Katelyn A Queen, Alisa Cario, Christopher L Berger, Jason Stumpff

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

染色体驱动蛋白 KIF22 的致病突变破坏了后期染色体分离

Alex F Thompson, Patrick R Blackburn, Noah S Arons, Sarah N Stevens, Dusica Babovic-Vuksanovic, Jane B Lian, Eric W Klee, Jason Stumpff

Chromosomally unstable tumor cells specifically require KIF18A for proliferation

染色体不稳定的肿瘤细胞特别需要 KIF18A 来增殖

Carolyn Marquis, Cindy L Fonseca, Katelyn A Queen, Lisa Wood, Sarah E Vandal, Heidi L H Malaby, Joseph E Clayton, Jason Stumpff

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding

驱动蛋白结合蛋白重塑驱动蛋白马达以防止微管结合

April L Solon, Zhenyu Tan, Katherine L Schutt, Lauren Jepsen, Sarah E Haynes, Alexey I Nesvizhskii, David Sept, Jason Stumpff, Ryoma Ohi, Michael A Cianfrocco

Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis

Kif18a 突变小鼠的微核形成稳定的微核包膜并且不会促进肿瘤发生

Leslie A Sepaniac, Whitney Martin, Louise A Dionne, Timothy M Stearns, Laura G Reinholdt, Jason Stumpff

The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

驱动蛋白-5尾部结构域直接调节运动结构域的机械化学循环,实现反平行微管滑动

Tatyana Bodrug, Elizabeth M Wilson-Kubalek #, Stanley Nithianantham #, Alex F Thompson #, April Alfieri #, Ignas Gaska, Jennifer Major, Garrett Debs, Sayaka Inagaki, Pedro Gutierrez, Larisa Gheber, Richard J McKenney, Charles Vaughn Sindelar, Ronald Milligan, Jason Stumpff, Steven S Rosenfeld, Scott