Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.

SHP2 介导的细胞外信号调节激酶激活受损，导致具有表皮生长因子受体激活突变的肺癌细胞对吉非替尼敏感