日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

阿尔茨海默病治疗药物Lecanemab通过诱导小胶质细胞中的淀粉样蛋白清除程序来减轻Aβ病理。

Albertini Giulia, Zielonka Magdalena, Cuypers Marie-Lynn, Snellinx An, Xu Ciana, Poovathingal Suresh, Wojno Marta, Davie Kristofer, van Lieshout Veerle, Craessaerts Katleen, Wolfs Leen, Pasciuto Emanuela, Jaspers Tom, Horré Katrien, Serneels Lurgarde, Fiers Mark, Dewilde Maarten, De Strooper Bart

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.

通过与髓鞘少突胶质细胞糖蛋白(一种中枢神经系统特异性蛋白)的额外结合,延长抗体在大脑中的半衰期

Cuypers Marie-Lynn, Jaspers Tom, Clerckx Jarne, Leekens Simon, Cawthorne Christopher, Bormans Guy, Cleeren Frederik, Geukens Nick, De Strooper Bart, Dewilde Maarten

Using anti‐Aβ antibodies to modulate the multi‐pronged human microglia response to Aβ pathology

利用抗Aβ抗体调节人类小胶质细胞对Aβ病理的多方面反应

Wang, Yuli; Li, Yingjie; Yi, Fei; Li, Junyu; Xie, Siwei; Peng, Qiyu; Xu, Jianfeng; Albertini, Giulia; Zielonka, Magdalena; Cuypers, Marie‐Lynn; van Lieshout, Veerle; Snellinx, An; Pasciuto, Emanuela; Wolfs, Leen; Craessaerts, Katleen; Horré, Katrien; Jaspers, Tom; Fiers, Mark; Dewilde, Maarten; De Strooper, Bart