日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation

功能获得性突变的p53通过抑制AMPK激活促进细胞生长和癌细胞代谢。

Zhou, Ge; Wang, Jiping; Zhao, Mei; Xie, Tong-Xin; Tanaka, Noriaki; Sano, Daisuke; Patel, Ameeta A; Ward, Alexandra M; Sandulache, Vlad C; Jasser, Samar A; Skinner, Heath D; Fitzgerald, Alison Lea; Osman, Abdullah A; Wei, Yongkun; Xia, Xuefeng; Songyang, Zhou; Mills, Gordon B; Hung, Mien-Chie; Caulin, Carlos; Liang, Jiyong; Myers, Jeffrey N

Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers

年轻非吸烟者口腔舌鳞状细胞癌的基因组与老年吸烟者的肿瘤相似。

Pickering, Curtis R; Zhang, Jiexin; Neskey, David M; Zhao, Mei; Jasser, Samar A; Wang, Jiping; Ward, Alexandra; Tsai, C Jillian; Ortega Alves, Marcus V; Zhou, Jane H; Drummond, Jennifer; El-Naggar, Adel K; Gibbs, Richard; Weinstein, John N; Wheeler, David A; Wang, Jing; Frederick, Mitchell J; Myers, Jeffrey N

Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells

TP53基因151位密码子脯氨酸被丝氨酸取代,赋予其功能获得性活性,导致头颈癌细胞产生抗凋亡能力并促进肿瘤进展。

Xie, Tong-Xin; Zhou, Ge; Zhao, Mei; Sano, Daisuke; Jasser, Samar A; Brennan, Richard G; Myers, Jeffrey N

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

头颈部鳞状细胞癌的外显子组测序揭示了 NOTCH1 的失活突变

Agrawal, Nishant; Frederick, Mitchell J; Pickering, Curtis R; Bettegowda, Chetan; Chang, Kyle; Li, Ryan J; Fakhry, Carole; Xie, Tong-Xin; Zhang, Jiexin; Wang, Jing; Zhang, Nianxiang; El-Naggar, Adel K; Jasser, Samar A; Weinstein, John N; Treviño, Lisa; Drummond, Jennifer A; Muzny, Donna M; Wu, Yuanqing; Wood, Laura D; Hruban, Ralph H; Westra, William H; Koch, Wayne M; Califano, Joseph A; Gibbs, Richard A; Sidransky, David; Vogelstein, Bert; Velculescu, Victor E; Papadopoulos, Nickolas; Wheeler, David A; Kinzler, Kenneth W; Myers, Jeffrey N

Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model

在原位小鼠模型中,靶向VEGFR2和EGFR的治疗可显著抑制未分化型甲状腺癌的生长。

Gule, Maria K; Chen, Yunyun; Sano, Daisuke; Frederick, Mitchell J; Zhou, Ge; Zhao, Mei; Milas, Zvonimir L; Galer, Chad E; Henderson, Ying C; Jasser, Samar A; Schwartz, David L; Bankson, James A; Myers, Jeffrey N; Lai, Stephen Y

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

对来自不同头颈部肿瘤部位的 85 个经基因组验证的细胞系进行组装和初步表征

Zhao Mei, Sano Daisuke, Pickering Curtis R, Jasser Samar A, Henderson Ying C, Clayman Gary L, Sturgis Erich M, Ow Thomas J, Lotan Reuben, Carey Thomas E, Sacks Peter G, Grandis Jennifer R, Sidransky David, Heldin Nils Erik, Myers Jeffrey N

The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck

Akt抑制剂KP372-1抑制头颈部鳞状细胞癌的增殖,并诱导其凋亡和失巢凋亡。

Mandal, Mahitosh; Younes, Maher; Swan, Eric A; Jasser, Samar A; Doan, Dao; Yigitbasi, Orhan; McMurphey, Andrea; Ludwick, James; El-Naggar, Adel K; Bucana, Cora; Mills, Gordon B; Myers, Jeffrey N