日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys

PD-1 靶向 IL-15 在食蟹猴中的药代动力学、药效学和毒性

Changhua Ji, Bing Kuang, Bernard S Buetow, Allison Vitsky, Yuanming Xu, Tzu-Hsuan Huang, Javier Chaparro-Riggers, Eugenia Kraynov, Diane Matsumoto

Direct control of CAR T cells through small molecule-regulated antibodies

通过小分子调节抗体直接控制 CAR-T 细胞

Spencer Park #, Edward Pascua #, Kevin C Lindquist #, Christopher Kimberlin, Xiaodi Deng, Yvonne S L Mak, Zea Melton, Theodore O Johnson, Regina Lin, Bijan Boldajipour, Robert T Abraham, Jaume Pons, Barbra Johnson Sasu, Thomas J Van Blarcom, Javier Chaparro-Riggers

One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics

一刀切的做法并不适用所有情况:探索多维空间以优化 T 细胞接合蛋白疗法

Wei Chen, Fan Yang, Carole Wang, Jatin Narula, Edward Pascua, Irene Ni, Sheng Ding, Xiaodi Deng, Matthew Ling-Hon Chu, Amber Pham, Xiaoyue Jiang, Kevin C Lindquist, Patrick J Doonan, Tom Van Blarcom, Yik Andy Yeung, Javier Chaparro-Riggers

Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex

共刺激CD27:CD70复合物的结构界定和相位依赖性激活

Weifeng Liu ,Zachary Maben ,Carole Wang ,Kevin C Lindquist ,Manqing Li ,Vinayak Rayannavar ,Ilsel Lopez Armenta ,Andrew Nager ,Edward Pascua ,Pawel K Dominik ,David Oyen ,Hui Wang ,Rachel Carson Roach ,Corey M Allan ,Lidia Mosyak ,Javier Chaparro-Riggers

An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity

优化的全长 FLT3/CD3 双特异性抗体表现出强效的抗白血病活性和可逆的血液学毒性

Yik Andy Yeung, Veena Krishnamoorthy, Danielle Dettling, Cesar Sommer, Kris Poulsen, Irene Ni, Amber Pham, Wei Chen, Sindy Liao-Chan, Kevin Lindquist, S Michael Chin, Allison Given Chunyk, Wenyue Hu, Barbra Sasu, Javier Chaparro-Riggers, Ivana Djuretic

Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery

具有关闭开关的同种异体 FLT3 CAR-T 细胞表现出对抗 AML 的强效活性,并且可以消耗以加快骨髓恢复

Cesar Sommer, Hsin-Yuan Cheng, Duy Nguyen, Danielle Dettling, Yik Andy Yeung, Janette Sutton, Moustafa Hamze, Julien Valton, Julianne Smith, Ivana Djuretic, Javier Chaparro-Riggers, Barbra J Sasu

Characterization and Comparison of GITR Expression in Solid Tumors

实体瘤中GITR表达的特征分析与比较

Luis Vence # ,Samantha L Bucktrout # ,Irina Fernandez Curbelo ,Jorge Blando ,Bevin M Smith ,Ashley E Mahne ,John C Lin ,Terrence Park ,Edward Pascua ,Tao Sai ,Javier Chaparro-Riggers ,Sumit K Subudhi ,Jorge B Scutti ,Maria G Higa ,Hao Zhao ,Shalini S Yadav ,Anirban Maitra ,Ignacio I Wistuba ,James P Allison ,Padmanee Sharma

Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity

配体阻断和膜近端结构域靶向抗 OX40 抗体介导强效 T 细胞刺激和抗肿瘤活性

Pamela Zhang, Guang Huan Tu, Jie Wei, Pamela Santiago, Lance R Larrabee, Sindy Liao-Chan, Tina Mistry, Matthew Ling-Hon Chu, Tao Sai, Kevin Lindquist, Hua Long, Javier Chaparro-Riggers, Shahram Salek-Ardakani, Yik Andy Yeung

Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

4-1BB/4-1BBL 复合物的结构以及 utomilumab 和 urelumab 的不同结合和功能特性

S Michael Chin, Christopher R Kimberlin, Zygy Roe-Zurz, Pamela Zhang, Allison Xu, Sindy Liao-Chan, Debasish Sen, Andrew R Nager, Nicole Schirle Oakdale, Colleen Brown, Feng Wang, Yuting Yang, Kevin Lindquist, Yik Andy Yeung, Shahram Salek-Ardakani, Javier Chaparro-Riggers

Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire

人类抗体库对金黄色葡萄球菌毒力因子的种系编码中和

Yik Andy Yeung, Davide Foletti, Xiaodi Deng, Yasmina Abdiche, Pavel Strop, Jacob Glanville, Steven Pitts, Kevin Lindquist, Purnima D Sundar, Marina Sirota, Adela Hasa-Moreno, Amber Pham, Jody Melton Witt, Irene Ni, Jaume Pons, David Shelton, Arvind Rajpal, Javier Chaparro-Riggers