日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy

CDK4/6 抑制可增强临床前模型中化疗和免疫检查点抑制剂联合治疗的抗肿瘤疗效,并增强接受化疗的小细胞肺癌患者的 T 细胞活化

Anne Y Lai #, Jessica A Sorrentino #, Konstantin H Dragnev, Jared M Weiss, Taofeek K Owonikoko, Julie A Rytlewski, Jill Hood, Zhao Yang, Rajesh K Malik, Jay C Strum, Patrick J Roberts

G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

G1T48(一种口服选择性雌激素受体降解剂)和 CDK4/6 抑制剂 lerociclib 可抑制内分泌抗性乳腺癌动物模型中的肿瘤生长

Kaitlyn J Andreano, Suzanne E Wardell, Jennifer G Baker, Taylor K Desautels, Robert Baldi, Christina A Chao, Kendall A Heetderks, Yeeun Bae, Rui Xiong, Debra A Tonetti, Lauren M Gutgesell, Jiong Zhao, Jessica A Sorrentino, Delita A Thompson, John E Bisi, Jay C Strum, Gregory R J Thatcher, John D Nor

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

短暂抑制 CDK4/6 可保护造血干细胞免于化疗引起的衰竭

Shenghui He, Patrick J Roberts, Jessica A Sorrentino, John E Bisi, Hannah Storrie-White, Renger G Tiessen, Karenann M Makhuli, William A Wargin, Henko Tadema, Ewoud-Jan van Hoogdalem, Jay C Strum, Rajesh Malik, Norman E Sharpless

CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC

CDK4/6 治疗干预和 CRPC 中紫杉烷类药物的可行替代方案

James P Stice, Suzanne E Wardell, John D Norris, Alexander P Yllanes, Holly M Alley, Victoria O Haney, Hannah S White, Rachid Safi, Peter S Winter, Kimberly J Cocce, Rigel J Kishton, Scott A Lawrence, Jay C Strum, Donald P McDonnell