MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance
MEK1/2 抑制剂停药可逆转由 BRAFV600E 扩增驱动的获得性耐药性，而 KRASG13D 扩增则促进 EMT 化学耐药性
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-019-09438-w
Matthew J Sale, Kathryn Balmanno, Jayeta Saxena, Eiko Ozono, Katarzyna Wojdyla, Rebecca E McIntyre, Rebecca Gilley, Anna Woroniuk, Karen D Howarth, Gareth Hughes, Jonathan R Dry, Mark J Arends, Pilar Caro, David Oxley, Susan Ashton, David J Adams, Julio Saez-Rodriguez, Paul D Smith, Simon J Cook1
