日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chronic lymphocytic leukemia with IGH::BCL3-translocation is characterized by a homogeneous and distinct genetic and epigenetic landscape

伴有IGH::BCL3易位的慢性淋巴细胞白血病具有同质且独特的遗传和表观遗传特征。

Drewes, Cosima; López, Cristina; Martinez-Manjón, Juan Emilio; Okeke, Nnamdi; Jebaraj, Billy; Bens, Susanne; Brändl, Björn; Dyer, Martin J S; Eichhorst, Barbara; Fischer, Anja; Fischer, Kirsten; Robrecht, Sandra; Hallek, Michael; Glaser, Selina; Hillebrecht, Sina; Jayne, Sandrine; Kretzmer, Helene; Mottok, Anja; Müller, Franz-Josef; Schneider, Christof; Ammerpohl, Ole; Del Val, Coral; Stilgenbauer, Stephan; Tausch, Eugen; Siebert, Reiner

The BH3-only protein NOXA is essential for apoptosis induction by BH3-mimetics targeting BCL2 or BCL-X(L) in DLBCL

BH3结构域蛋白NOXA对于靶向BCL2或BCL-X(L)的BH3模拟物在弥漫性大B细胞淋巴瘤(DLBCL)中诱导细胞凋亡至关重要。

Yildirim, Nahide; Anders, Marius; Smith, Victoria M; Jayne, Sandrine; Assmann, Moritz; Jukes-Jones, Rebekah; Dyer, Martin J S; Vogler, Meike

The unfolded protein response influences therapy outcome and disease progression in chronic lymphocytic leukaemia.

未折叠蛋白反应影响慢性淋巴细胞白血病的治疗结果和疾病进展

Khan Umair Tahir, Clarke Kim, Eagle Gina, Oates Melanie, Hillmen Peter, Jayne Sandrine, Dyer Martin J S, Phipps Alex, Falciani Francesco, Jenkins Rosalind E, Pettitt Andrew R

In vitro comparison of CD20xCD3 bispecific antibodies against diffuse large B-cell lymphoma (DLBCL) cell lines with different levels of expression of CD20

体外比较CD20×CD3双特异性抗体对不同CD20表达水平的弥漫性大B细胞淋巴瘤(DLBCL)细胞系的活性

Bray, Joshua S; Thomas, Gethin R; Smith, Victoria M; Wright, Adam; Jayne, Sandrine; Dyer, Martin J S; Walter, Harriet S

Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death.

利用 PROTACs 靶向降解 1 类 HDACs 可高效诱导 DLBCL 细胞死亡

Alraddadi Abdullah, Smalley Joshua P, Alzahrani Wael, Saleh Anes, Al-Mansour Fares, He Buwei, Cao Thong H, Jayne Sandrine, Dyer Martin, Hodgkinson James T, Jones Donald J L, Cowley Shaun M, Macip Salvador

The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to RCC1::IRF4 fusion

慢性淋巴细胞白血病中常见的染色体易位t(1;6)(p35.3;p25.2)会导致RCC1::IRF4融合。

Jayne, Sandrine; López, Cristina; Put, Natalie; Nagel, Inga; Lierman, Els; Penas, Eva Maria Murga; Michaux, Lucienne; Ahearne, Matthew J; Walter, Harriet S; Bens, Susanne; Drewes, Cosima; Szczepanowski, Monika; Schlesner, Matthias; Rosenstiel, Philip; Wlodarska, Iwona; Siebert, Reiner; Dyer, Martin J S

Monitoring of molecular responses to tirabrutinib in a cohort of exceptional responders with relapsed/refractory mantle cell lymphoma

对一组复发/难治性套细胞淋巴瘤特效患者进行替拉替尼分子反应监测

Alqahtani, Abdullah N M; Jayne, Sandrine; Ahearne, Matthew J; Trethewey, Christopher S; Duraisingham, Sai S; Lehmann, Susann; Cowley, Caroline M; Dyer, Martin J S; Walter, Harriet S

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

临床批准的BTK抑制剂对全长BTK构象的影响以及慢性淋巴细胞白血病中BTK耐药突变的发展分析

Joseph, Raji E; Wales, Thomas E; Jayne, Sandrine; Britton, Robert G; Fulton, D Bruce; Engen, John R; Dyer, Martin J S; Andreotti, Amy H

BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib

接受替拉布替尼治疗的慢性淋巴细胞白血病患者的BTK突变

Jackson, Ross A; Britton, Robert G; Jayne, Sandrine; Lehmann, Susann; Cowley, Caroline M; Trethewey, Christopher S; Smith, Victoria M; Schmid, Ralf; Fegan, Christopher; Walter, Harriet S; Dyer, Martin J S

Limitations of Monitoring Disease Progression Using Circulating Tumor DNA in Lymphoma: An Example From Primary Cutaneous DLBCL Leg-type

利用循环肿瘤DNA监测淋巴瘤疾病进展的局限性:以原发性皮肤弥漫性大B细胞淋巴瘤腿型为例

Trethewey, Christopher S; Walter, Harriet S; Alqahtani, Abdullah N M; Schmid, Ralf; Guttery, David S; Griffin, Yvette; Ahearne, Matthew J; Saldanha, Gerald S; Jayne, Sandrine P N; Dyer, Martin J S