Jean-Alphonse相关文献与解析，生知库 | 链接生命科学的每一步

Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy

利用抗体-药物偶联物靶向黑色素瘤中内皮素受体 B 的活化变构构象：机制和治疗效果

Amaury Herbet #, Marie Hautière #, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

肿瘤

An intracellular VHH targeting the Luteinizing Hormone receptor modulates G protein-dependent signaling and steroidogenesis

针对促黄体激素受体的细胞内 VHH 调节 G 蛋白依赖性信号传导和类固醇生成

期刊:Molecular and Cellular Endocrinology

影响因子:3.8

doi:10.1016/j.mce.2024.112235

Camille Gauthier, Pauline Raynaud, Frédéric Jean-Alphonse, Amandine Vallet, Océane Vaugrente, Vinesh Jugnarain, Thomas Boulo, Christophe Gauthier, Eric Reiter, Gilles Bruneau, Pascale Crépieux

Editorial: Pharmacology of endocrine related GPCRs

社论：内分泌相关G蛋白偶联受体的药理学

期刊:Frontiers in Endocrinology

影响因子:

doi:10.3389/fendo.2024.1379108

De Pascali, Francesco; Hanyaloglu, Aylin; Jean-Alphonse, Frederic; Potì, Francesco; Reiter, Eric

信号转导

发表日期：2024

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Combined Multiplexed Phage Display, High-Throughput Sequencing, and Functional Assays as a Platform for Identifying Modulatory VHHs Targeting the FSHR

结合多重噬菌体展示、高通量测序和功能分析作为识别针对 FSHR 的调节性 VHH 的平台

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms242115961

Anielka Zehnaker, Amandine Vallet, Juliette Gourdon, Caterina Sarti, Vinesh Jugnarain, Maya Haj Hassan, Laetitia Mathias, Camille Gauthier, Pauline Raynaud, Thomas Boulo, Linda Beauclair, Yves Bigot, Livio Casarini, Pascale Crépieux, Anne Poupon, Benoît Piégu, Frédéric Jean-Alphonse, Gilles Bruneau,

FSH

发表日期：2023

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Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell

小鼠睾丸间质肿瘤细胞中 FSH、TSH、PTH、Kp、OT 及 LH 的高灵敏度体外生物测定

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms241512047

Danièle Klett, Lucie Pellissier, Didier Lomet, Flavie Derouin-Tochon, Vincent Robert, Thi Mong Diep Nguyen, Anne Duittoz, Eric Reiter, Yann Locatelli, Joëlle Dupont, Hugues Dardente, Frédéric Jean-Alphonse, Yves Combarnous

Intracellular VHHs to monitor and modulate GPCR signaling

细胞内VHH监测和调节GPCR信号传导

期刊:Frontiers in Endocrinology

影响因子:4.6

doi:10.3389/fendo.2022.1048601

Raynaud, Pauline; Gauthier, Camille; Jugnarain, Vinesh; Jean-Alphonse, Frédéric; Reiter, Eric; Bruneau, Gilles; Crépieux, Pascale

Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36

天然甲状旁腺激素相关蛋白1至141相对于其N端片段1至36的偏向性GPCR信号传导

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2022.102332

Peña, Karina A; White, Alex D; Savransky, Sofya; Castillo, Ignacio Portales; Jean-Alphonse, Frédéric G; Gardella, Thomas J; Sutkeviciute, Ieva; Vilardaga, Jean-Pierre

Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor

低分子量偏向促卵泡激素受体激动剂的药理学表征

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms22189850

Francesco De Pascali, Mohammed Akli Ayoub, Riccardo Benevelli, Silvia Sposini, Jordan Lehoux, Nathalie Gallay, Pauline Raynaud, Flavie Landomiel, Frédéric Jean-Alphonse, Christophe Gauthier, Lucie P Pellissier, Pascale Crépieux, Anne Poupon, Asuka Inoue, Nicolas Joubert, Marie-Claude Viaud-Massuard,

信号转导

发表日期：2021

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Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

cAMP 生成的空间偏差决定了对 PTH 1 型受体激活的生物反应

期刊:Science Signaling

影响因子:

doi:10.1126/scisignal.abc5944

Alex D White, Karina A Peña, Lisa J Clark, Christian Santa Maria, Shi Liu, Frédéric G Jean-Alphonse, Ji Young Lee, Saifei Lei, Zhiqiang Cheng, Chia-Ling Tu, Fei Fang, Nicholas Szeto, Thomas J Gardella, Kunhong Xiao, Samuel H Gellman, Ivet Bahar, Ieva Sutkeviciute, Wenhan Chang, Jean-Pierre Vilardaga

信号转导

发表日期：2021

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Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties.

牛 FFAR2/GPR43 的内源性配体表现出不同的药理特性

Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy

利用抗体-药物偶联物靶向黑色素瘤中内皮素受体 B 的活化变构构象：机制和治疗效果

An intracellular VHH targeting the Luteinizing Hormone receptor modulates G protein-dependent signaling and steroidogenesis

针对促黄体激素受体的细胞内 VHH 调节 G 蛋白依赖性信号传导和类固醇生成

Editorial: Pharmacology of endocrine related GPCRs

社论：内分泌相关G蛋白偶联受体的药理学

Combined Multiplexed Phage Display, High-Throughput Sequencing, and Functional Assays as a Platform for Identifying Modulatory VHHs Targeting the FSHR

结合多重噬菌体展示、高通量测序和功能分析作为识别针对 FSHR 的调节性 VHH 的平台

Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell

小鼠睾丸间质肿瘤细胞中 FSH、TSH、PTH、Kp、OT 及 LH 的高灵敏度体外生物测定

Intracellular VHHs to monitor and modulate GPCR signaling

细胞内VHH监测和调节GPCR信号传导

Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36

天然甲状旁腺激素相关蛋白1至141相对于其N端片段1至36的偏向性GPCR信号传导

Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor

低分子量偏向促卵泡激素受体激动剂的药理学表征

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

cAMP 生成的空间偏差决定了对 PTH 1 型受体激活的生物反应