文献库，生知库 | 链接生命科学的每一步

日期影响因子

PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma

PPARα介导的脂质代谢重编程支持头颈部鳞状细胞癌的抗EGFR治疗耐药性

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-56675-3

Valentin Van den Bossche # ，Julie Vignau # ，Engy Vigneron # ，Isabella Rizzi ，Hannah Zaryouh ，An Wouters ，Jérôme Ambroise ，Steven Van Laere ，Simon Beyaert ，Raphaël Helaers ，Cédric van Marcke ，Lionel Mignion ，Elise Y Lepicard ，Bénédicte F Jordan ，Céline Guilbaud ，Olivier Lowyck ，Hajar Dahou ，Antonella Mendola ，Manon Desgres ，Léo Aubert ，Isabelle Gerin ，Guido T Bommer ，Romain Boidot ，Perrine Vermonden ，Aurélien Warnant ，Yvan Larondelle ，Jean-Pascal Machiels ，Olivier Feron ，Sandra Schmitz ，Cyril Corbet

细胞生物学

代谢重编程

发表日期：2025

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Spatial Transcriptomic Analysis of Surgical Resection Specimens of Primary Head and Neck Squamous Cell Carcinoma Treated with Afatinib in a Window-of-Opportunity Study (EORTC90111-24111)

在机会窗口研究中，对接受阿法替尼治疗的原发性头颈部鳞状细胞癌手术切除标本进行空间转录组分析（EORTC90111-24111）

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms26051830.

Simon Beyaert ,Axelle Loriot ,Jean-Pascal Machiels ,Sandra Schmitz

发表日期：2025

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Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone

针对去势抵抗性前列腺癌的 MET 抑制：利妥木单抗联合米托蒽醌和泼尼松的随机 II 期研究和生物标志物分析

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-12-2605

Charles J Ryan, Mark Rosenthal, Siobhan Ng, Joshi Alumkal, Joel Picus, Gwenaëlle Gravis, Karim Fizazi, Frédéric Forget, Jean-Pascal Machiels, Sandy Srinivas, Min Zhu, Rui Tang, Kelly S Oliner, Yizhou Jiang, Elwyn Loh, Sarita Dubey, Winald R Gerritsen

发表日期：2024

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Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

针对 CC 趋化因子配体 2 (CCL2) 的人类单克隆抗体 carlumab (CNTO 888) 治疗转移性去势抵抗性前列腺癌的 2 期研究

期刊:Investigational New Drugs

doi:10.1007/s10637-012-9869-8

Kenneth J Pienta, Jean-Pascal Machiels, Dirk Schrijvers, Boris Alekseev, Mikhail Shkolnik, Simon J Crabb, Susan Li, Shobha Seetharam, Thomas A Puchalski, Chris Takimoto, Yusri Elsayed, Fitzroy Dawkins, Johann S de Bono

发表日期：2024

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Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck

细胞周期蛋白依赖性激酶 4/6 抑制剂 Ribociclib 和西妥昔单抗在头颈部鳞状细胞癌中的联合作用的临床前评估

doi:10.3390/cancers13061251

Gabrielle van Caloen, Sandra Schmitz, Cédric van Marcke, Xavier Caignet, Antonella Mendola, Sébastien Pyr Dit Ruys, Pierre P Roger, Didier Vertommen, Jean-Pascal Machiels

发表日期：2021

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Preclinical Activity of Ribociclib in Squamous Cell Carcinoma of the Head and Neck

Ribociclib 在头颈部鳞状细胞癌中的临床前活性

期刊:Molecular Cancer Therapeutics

影响因子:5.3

doi:10.1158/1535-7163.MCT-19-0695

Gabrielle van Caloen, Sandra Schmitz, Mariama El Baroudi, Xavier Caignet, Sébastien Pyr Dit Ruys, Pierre P Roger, Didier Vertommen, Jean-Pascal Machiels

发表日期：2020

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Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer

通过阵列比较基因组杂交技术鉴定出17q染色体上一个在BRCA1突变三阴性乳腺癌中高度复发的新扩增子

期刊:Breast Cancer Research

影响因子:6.1

doi:10.1186/s13058-014-0466-y.

Sébastien Toffoli ,Isabelle Bar ,Fadi Abdel-Sater ,Paul Delrée ,Pascale Hilbert ,Frédéric Cavallin ,Fabrice Moreau ,Wim Van Criekinge ,Magali Lacroix-Triki ,Mario Campone ,Anne-Laure Martin ,Henri Roché ,Jean-Pascal Machiels ,Javier Carrasco ,Jean-Luc Canon

发表日期：2014

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A phase II study of the cancer vaccine TG4010 alone and in combination with cytokines in patients with metastatic renal clear-cell carcinoma: clinical and immunological findings

癌症疫苗 TG4010 单独和与细胞因子联合治疗转移性肾透明细胞癌患者的 II 期研究：临床和免疫学发现

期刊:Cancer Immunology Immunotherapy

影响因子:8.1

doi:10.1007/s00262-010-0935-9

Stéphane Oudard, Olivier Rixe, Benoit Beuselinck, Claude Linassier, Eugeniu Banu, Jean-Pascal Machiels, Marion Baudard, François Ringeisen, Thierry Velu, Marie-Aude Lefrere-Belda, Jean-Marc Limacher, W H Fridman, Michel Azizi, Bruce Acres, Eric Tartour

发表日期：2011

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Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer

直肠癌对西妥昔单抗的分子反应和术前以西妥昔单抗为基础的放化疗的疗效

期刊:Journal of Clinical Oncology

影响因子:42.1

doi:10.1200/JCO.2008.18.5033

Annelies Debucquoy, Karin Haustermans, Anneleen Daemen, Selda Aydin, Louis Libbrecht, Olivier Gevaert, Bart De Moor, Sabine Tejpar, William H McBride, Freddy Penninckx, Pierre Scalliet, Christopher Stroh, Soetkin Vlassak, Christine Sempoux, Jean-Pascal Machiels

发表日期：2009

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