日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity

哌拉西嗪直接与 PAX3::FOXO1 融合蛋白结合并抑制其转录活性

Kay Nakazawa #, Taryn Shaw #, Young K Song, Marilyn Kouassi-Brou, Anna Molotkova, Purushottam B Tiwari, Hsien-Chao Chou, Xinyu Wen, Jun S Wei, Emre Deniz, Jeffrey A Toretsky, Charles Keller, Frederic G Barr, Javed Khan, Aykut Üren

Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma

mRNA 剪接的综合分析表明,GC 含量表明尤文氏肉瘤中的盒式外显子包含发生了改变

Garrett T Graham, Saravana P Selvanathan, Stefan K Zöllner, Emily Stahl, Adam Shlien, Natasha J Caplen, Aykut Üren, Jeffrey A Toretsky

Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations

结合脂质标记和点击化学分离细胞外囊泡,实现致癌基因变异的无创检测

Na Sun, Benjamin V Tran, Zishan Peng, Jing Wang, Ceng Zhang, Peng Yang, Tiffany X Zhang, Josephine Widjaja, Ryan Y Zhang, Wenxi Xia, Alexandra Keir, Jia-Wei She, Hsiao-Hua Yu, Jing-Jong Shyue, Hongguang Zhu, Vatche G Agopian, Renjun Pei, James S Tomlinson, Jeffrey A Toretsky, Steven J Jonas, Noah Fe

Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells

氯法拉滨通过抑制尤文氏肉瘤细胞中的 CD99 诱导 ERK/MSK/CREB 活化

Handan Sevim, Haydar Çelik, Levent Düşünceli, Ceyda S Ceyhan, Anna Molotkova, Kay Nakazawa, Garrett T Graham, Jeffrey R Petro, Jeffrey A Toretsky, Aykut Üren

Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies

将纳米结构微芯片与共价化学结合,可以纯化肉瘤衍生的细胞外囊泡,用于下游功能研究

Jiantong Dong, Ryan Y Zhang, Na Sun, Junhui Hu, Matthew D Smalley, Anqi Zhou, Hua Yue, Winston Rothermich, Mengxiang Chen, Jiayuan Chen, Jinglei Ye, Pai-Chi Teng, Dongping Qi, Jeffrey A Toretsky, James S Tomlinson, Mengyuan Li, Paul S Weiss, Steven J Jonas, Noah Federman, Lily Wu, Meiping Zhao, Hsia

EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex

EWS-FLI1 调节 ARID1A 的选择性剪接,通过 BAF 复合物揭示新的致癌功能

Saravana P Selvanathan, Garrett T Graham, Alexander R Grego, Tabari M Baker, J Robert Hogg, Mark Simpson, Mona Batish, Brian Crompton, Kimberly Stegmaier, Eleni M Tomazou, Heinrich Kovar, Aykut Üren, Jeffrey A Toretsky

Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis

靶向抑制组蛋白去乙酰化酶可通过未被重视的 EWS-FLI1/HDAC3/HSP90 信号轴抑制尤文氏肉瘤肿瘤生长

Yan Ma, Michael Baltezor, Lian Rajewski, Jennifer Crow, Glenson Samuel, Vincent S Staggs, Katherine M Chastain, Jeffrey A Toretsky, Scott J Weir, Andrew K Godwin

EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

EWS-FLI1 增加转录以引起 R 环并阻止尤文氏肉瘤中的 BRCA1 修复

Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V Pragathi Masamsetti, Sydney Roston, Elizabeth R Lawlor, Jeffrey A Toretsky, Kimberly Stegmaier, Stephen L Lessnick, Yidong Chen, Alexander J R Bishop

Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99

氯法拉滨通过与 CD99 直接结合的新型分子机制抑制尤文氏肉瘤生长

Haydar Çelik, Marika Sciandra, Bess Flashner, Elif Gelmez, Neslihan Kayraklıoğlu, David V Allegakoen, Jeff R Petro, Erin J Conn, Sarah Hour, Jenny Han, Lalehan Oktay, Purushottam B Tiwari, Mutlu Hayran, Brent T Harris, Maria Cristina Manara, Jeffrey A Toretsky, Katia Scotlandi, Aykut Üren

Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities

组合药物筛选确定尤文氏肉瘤特异性敏感性

Branka Radic-Sarikas, Kalliopi P Tsafou, Kristina B Emdal, Theodore Papamarkou, Kilian V M Huber, Cornelia Mutz, Jeffrey A Toretsky, Keiryn L Bennett, Jesper V Olsen, Søren Brunak, Heinrich Kovar, Giulio Superti-Furga