日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A monofunctional-like mutant of DNA glycosylase NTHL1 changes the dynamics of DNA repair during acute oxidative stress

DNA糖基化酶NTHL1的单功能样突变体改变了急性氧化应激期间DNA修复的动态过程。

Haslam, James; Rudolfova, Natalie; Zhou, Kaixin; Homan, Evert; Jemth, Ann-Sofie; Michel, Maurice; Helleday, Thomas; Mortusewicz, Oliver

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

核碱基催化剂用于8-氧鸟嘌呤DNA糖基化酶1的酶促活化

Hank, Emily C; D'Arcy-Evans, Nicholas D; Scaletti, Emma Rose; Benítez-Buelga, Carlos; Wallner, Olov; Ortis, Florian; Zhou, Kaixin; Meng, Liuzhen; Del Prado, Alicia; Calvo, Patricia; Almlöf, Ingrid; Wiita, Elisée; Nierlin, Karen; Košenina, Sara; Krämer, Andreas; Eddershaw, Alice; Kehler, Mario; Long, Maeve; Jemth, Ann-Sofie; Dawson, Holly; Stewart, Josephine; Dickey, Adam; Astorga, Mikhael E; Varga, Marek; Homan, Evert J; Scobie, Martin; Knapp, Stefan; Sastre, Leandro; Stenmark, Pål; de Vega, Miguel; Helleday, Thomas; Michel, Maurice

Defining short linear motif binding determinants by phage display-based deep mutational scanning.

通过基于噬菌体展示的深度突变扫描确定短线性基序结合决定簇

Benz Caroline, Maassen Lars, Simonetti Leandro, Mihalic Filip, Lindqvist Richard, Tsitsa Ifigenia, Konstantinou Aimiliani, Jemth Per, Överby Anna K, Davey Norman E, Ivarsson Ylva

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

合成代谢类固醇司坦唑醇是人类 MutT 同源物 1 的强效抑制剂。

Scaletti Hutchinson, Emma; Gustafsson Westergren, Robert; Almlöf, Ingrid; Jemth, Ann-Sofie; Scobie, Martin; Warpman Berglund, Ulrika; Helleday, Thomas; Stenmark, Pål

Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes

辐鳍鱼中基序介导的p53/MDM2相互作用的动态演化,其根本在于亲和力的保守性而非序列的保守性

Mihalič, Filip; Arcila, Dahiana; Pettersson, Mats E; Farkhondehkish, Pouria; Andersson, Eva; Andersson, Leif; Betancur-R, Ricardo; Jemth, Per

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

通过综合筛选流程鉴定和评价针对 dNTPase SAMHD1 的小分子抑制剂

Si Min Zhang ,Cynthia B J Paulin ,Huazhang Shu ,Miriam Yagüe-Capilla ,Maurice Michel ,Petra Marttila ,Florian Ortis ,Henri Colyn Bwanika ,Christopher Dirks ,Rajagopal Papagudi Venkatram ,Elisée Wiita ,Ann-Sofie Jemth ,Ingrid Almlöf ,Olga Loseva ,Femke M Hormann ,Tobias Koolmeister ,Erika Linde ,Sun Lee ,Sabin Llona-Minguez ,Martin Haraldsson ,Hanna Axelsson ,Kia Strömberg ,Evert J Homan ,Martin Scobie ,Thomas Lundbäck ,Thomas Helleday ,Sean G Rudd

Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions

古斯塔夫森综合征是由 RBMX 中的框内缺失引起的,与可能受到干扰的 SH3 域相互作用有关

Josefin Johansson, Sarah Lidéus, Carina Frykholm, Cecilia Gunnarsson, Filip Mihalic, Sanna Gudmundsson, Sara Ekvall, Anna-Maja Molin, Mai Pham, Mauno Vihinen, Kristina Lagerstedt-Robinson, Ann Nordgren, Per Jemth, Adam Ameur, Göran Annerén, Maria Wilbe, Marie-Louise Bondeson2

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

甲酸盐溢出导致 MTHFD1 抑制癌细胞中有毒叶酸被捕获

Alanna C Green #, Petra Marttila #, Nicole Kiweler #, Christina Chalkiadaki, Elisée Wiita, Victoria Cookson, Antoine Lesur, Kim Eiden, François Bernardin, Karl S A Vallin, Sanjay Borhade, Maeve Long, Elahe Kamali Ghahe, Julio J Jiménez-Alonso, Ann-Sofie Jemth, Olga Loseva, Oliver Mortusewicz, Marian

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

通过鉴定SARS-CoV-2蛋白结构域与人肽配体之间基于基序的相互作用,可以精确定位抗病毒靶点。

Filip Mihalič ,Caroline Benz ,Eszter Kassa ,Richard Lindqvist ,Leandro Simonetti ,Raviteja Inturi ,Hanna Aronsson ,Eva Andersson ,Celestine N Chi ,Norman E Davey ,Anna K Överby ,Per Jemth ,Ylva Ivarsson

Rescue of Escherichia coli auxotrophy by de novo small proteins

通过从头小蛋白拯救营养缺陷型大肠杆菌

Babina, Arianne M; Surkov, Serhiy; Ye, Weihua; Jerlström-Hultqvist, Jon; Larsson, Mårten; Holmqvist, Erik; Jemth, Per; Andersson, Dan I; Knopp, Michael