日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors

TPST-1120(一种 PPARα 抑制剂)作为单药疗法或与纳武利尤单抗联合疗法治疗晚期实体瘤患者的首次人体 I 期试验

Yarchoan, Mark; Powderly, John D; Bastos, Bruno R; Karasic, Thomas B; Crysler, Oxana V; Munster, Pamela N; McKean, Meredith A; Emens, Leisha A; Saenger, Yvonne M; Ged, Yasser; Stagg, Robert; Smith, Steven; Whiting, Chan C; Moon, Anne; Prasit, Peppi; Jenkins, Yonchu; Standifer, Nathan; Dubensky, Thomas W; Whiting, Sam H; Ulahannan, Susanna V

Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial

Telaglenastat联合Cabozantinib或Everolimus治疗晚期或转移性肾细胞癌:一项开放标签I期试验

Meric-Bernstam, Funda; Tannir, Nizar M; Iliopoulos, Othon; Lee, Richard J; Telli, Melinda L; Fan, Alice C; DeMichele, Angela; Haas, Naomi B; Patel, Manish R; Harding, James J; Voss, Martin H; Owonikoko, Taofeek K; Carthon, Bradley; Srinivasan, Ramaprasad; Bendell, Johanna C; Jenkins, Yonchu; Whiting, Sam H; Orford, Keith; Bennett, Mark K; Bauer, Todd M

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

AMPK激活剂R419可改善肥胖小鼠的运动能力和骨骼肌胰岛素敏感性。

Marcinko, Katarina; Bujak, Adam L; Lally, James S V; Ford, Rebecca J; Wong, Tammy H; Smith, Brennan K; Kemp, Bruce E; Jenkins, Yonchu; Li, Wei; Kinsella, Todd M; Hitoshi, Yasumichi; Steinberg, Gregory R

Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways

对高脂饮食诱导肥胖的小鼠进行全球代谢物分析,并长期使用 AMPK 激活剂 R118 或二甲双胍进行治疗,结果显示代谢途径存在组织选择性改变。

Jenkins, Yonchu; Sun, Tian-Qiang; Li, Yingwu; Markovtsov, Vadim; Uy, Gerald; Gross, Lisa; Goff, Dane A; Shaw, Simon J; Boralsky, Luke; Singh, Rajinder; Payan, Donald G; Hitoshi, Yasumichi

Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.

通过基于图像的表型筛选鉴定的 Aurora 激酶抑制剂 R763/AS703569 的临床前表征

McLaughlin John, Markovtsov Vadim, Li Hui, Wong Steve, Gelman Marina, Zhu Yanhong, Franci Christian, Lang D Wayne, Pali Erlina, Lasaga Joe, Low Caroline, Zhao Feifei, Chang Betty, Gururaja Tarikere L, Xu Weiduan, Baluom Muhammad, Sweeny David, Carroll David, Sran Arvinder, Thota Sambaiah, Parmer Manjeet, Romane Angela, Clemens George, Grossbard Elliott, Qu Kunbin, Jenkins Yonchu, Kinoshita Taisei, Taylor Vanessa, Holland Sacha J, Argade Ankush, Singh Rajinder, Pine Polly, Payan Donald G, Hitoshi Yasumichi

Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth

UHRF1(一种核内RING指蛋白)的泛素连接酶活性在肿瘤细胞生长中起着关键作用

Jenkins, Yonchu; Markovtsov, Vadim; Lang, Wayne; Sharma, Poonam; Pearsall, Denise; Warner, Justin; Franci, Christian; Huang, Betty; Huang, Jianing; Yam, George C; Vistan, Joseph P; Pali, Erlina; Vialard, Jorge; Janicot, Michel; Lorens, James B; Payan, Donald G; Hitoshi, Yasumichi