日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia

确定针对 CBFA2T3::GLIS2 急性髓系白血病的靶向治疗方法

Fanny Gonzales,Constanze Schneider,Gabriela Alexe,Shan Lin,Delan Khalid,Montserrat Alvarez,Allen Basanthakumar,Jana M Ellegast,Lucy Merickel,Silvi Salhotra,Audrey Taillon,Mariateresa Giaimo,Mark Wunderlich,Marc Ansari,Jennifer A Perry,Barbara Degar,Yana Pikman,Kimberly Stegmaier

Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts

利用细胞内在炎症反应杀死急性髓系白血病原始细胞

Jana M Ellegast ,Gabriela Alexe ,Amanda Hamze ,Shan Lin ,Hannah J Uckelmann ,Philipp J Rauch ,Maxim Pimkin ,Linda S Ross ,Neekesh V Dharia ,Amanda L Robichaud ,Amy Saur Conway ,Delan Khalid ,Jennifer A Perry ,Mark Wunderlich ,Lina Benajiba ,Yana Pikman ,Behnam Nabet ,Nathanael S Gray ,Stuart H Orkin ,Kimberly Stegmaier

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

Menin-MLL抑制剂可诱导特定的染色质改变,并在MLL重排白血病模型中根除疾病。

Andrei V Krivtsov,Kathryn Evans,Jayant Y Gadrey,Benjamin K Eschle,Charlie Hatton,Hannah J Uckelmann,Kenneth N Ross,Florian Perner,Sarah N Olsen,Tara Pritchard,Lisa McDermott,Connor D Jones,Duohui Jing,Ali Braytee,Diego Chacon,Eric Earley,Brian M McKeever,David Claremon,Andrew J Gifford,Heather J Lee,Beverly A Teicher,John E Pimanda,Dominik Beck,Jennifer A Perry,Malcolm A Smith,Gerard M McGeehan,Richard B Lock,Scott A Armstrong

Molecular markers for corneal epithelial cells in larval vs. adult Xenopus frogs

非洲爪蟾幼蛙与成蛙角膜上皮细胞的分子标记

Sonam, Surabhi; Srnak, Jennifer A; Perry, Kimberly J; Henry, Jonathan J

The dTAG system for immediate and target-specific protein degradation

dTAG 系统可实现即时且靶向的蛋白质降解

Behnam Nabet, Justin M Roberts, Dennis L Buckley, Joshiawa Paulk, Shiva Dastjerdi, Annan Yang, Alan L Leggett, Michael A Erb, Matthew A Lawlor, Amanda Souza, Thomas G Scott, Sarah Vittori, Jennifer A Perry, Jun Qi, Georg E Winter, Kwok-Kin Wong, Nathanael S Gray, James E Bradner

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

通过缀合无效的布罗莫结构域和 VHL 配体的功能性 TRIM24 降解剂

Lara N Gechijian, Dennis L Buckley, Matthew A Lawlor, Jaime M Reyes, Joshiawa Paulk, Christopher J Ott, Georg E Winter, Michael A Erb, Thomas G Scott, Mousheng Xu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Nicholas P Kwiatkowski, Jennifer A Perry, Jun Qi, Nathanael S Gray, James E Bradner

YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis

YAP1 介导的 USP31 抑制可增强 NFκB 活性,促进肉瘤形成

Shuai Ye, Matthew A Lawlor, Adrian Rivera-Reyes, Shaun Egolf, Susan Chor, Koreana Pak, Gabrielle E Ciotti, Avery C Lee, Gloria E Marino, Jennifer Shah, David Niedzwicki, Kristy Weber, Paul M C Park, Md Zahidul Alam, Alison Grazioli, Malay Haldar, Mousheng Xu, Jennifer A Perry, Jun Qi, T S Karin Eisi

Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors

结构引导设计和开发强效且选择性的双溴结构域 4 (BRD4)/Polo 样激酶 1 (PLK1) 抑制剂

Shuai Liu, Hailemichael O Yosief, Lingling Dai, He Huang, Gagan Dhawan, Xiaofeng Zhang, Alex M Muthengi, Justin Roberts, Dennis L Buckley, Jennifer A Perry, Lei Wu, James E Bradner, Jun Qi, Wei Zhang

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

PRMT1介导的翻译调控是癌症的关键弱点

Jessie Hao-Ru Hsu, Benjamin Hubbell-Engler, Guillaume Adelmant, Jialiang Huang, Cailin E Joyce, Francisca Vazquez, Barbara A Weir, Philip Montgomery, Aviad Tsherniak, Andrew O Giacomelli, Jennifer A Perry, Jennifer Trowbridge, Yuko Fujiwara, Glenn S Cowley, Huafeng Xie, Woojin Kim, Carl D Novina, Wi

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer

EZH2 致癌失调为肺癌靶向治疗提供了机会

Haikuo Zhang, Jun Qi, Jaime M Reyes, Lewyn Li, Prakash K Rao, Fugen Li, Charles Y Lin, Jennifer A Perry, Matthew A Lawlor, Alexander Federation, Thomas De Raedt, Yvonne Y Li, Yan Liu, Melissa A Duarte, Yanxi Zhang, Grit S Herter-Sprie, Eiki Kikuchi, Julian Carretero, Charles M Perou, Jacob B Reibel,