日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction

发现并优化含 WD 重复序列蛋白 5-MYC 蛋白质-蛋白质相互作用的水杨酸衍生磺胺类抑制剂

Jonathan D Macdonald, Selena Chacón Simon, Changho Han, Feng Wang, J Grace Shaw, Jennifer E Howes, Jiqing Sai, Joannes P Yuh, Demarco Camper, Bethany M Alicie, Joseph Alvarado, Sameer Nikhar, William Payne, Erin R Aho, Joshua A Bauer, Bin Zhao, Jason Phan, Lance R Thomas, Olivia W Rossanese, William

Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1

小分子介导的 RAS 激活引发磷酸化 ERK 水平的双相调节,该调节通过对 SOS1 的负反馈进行

Jennifer E Howes, Denis T Akan, Michael C Burns, Olivia W Rossanese, Alex G Waterson, Stephen W Fesik

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

高通量筛选可识别与 RAS:SOS:RAS 复合物结合并干扰 RAS 信号的小分子

Michael C Burns, Jennifer E Howes, Qi Sun, Andrew J Little, DeMarco V Camper, Jason R Abbott, Jason Phan, Taekyu Lee, Alex G Waterson, Olivia W Rossanese, Stephen W Fesik