日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

肿瘤内缺氧通过慢性激活整合应激反应转录因子ATF4促进CD8+ T细胞功能障碍

Coral Del Mar Alicea Pauneto ,Brian P Riesenberg ,Evelyn J Gandy ,Andrew S Kennedy ,Genevieve T Clutton ,Jessica W Hem ,Katie E Hurst ,Elizabeth G Hunt ,Jarred M Green ,Brian C Miller ,Steven P Angus ,Gary L Johnson ,Robert J Esther ,Jennifer L Guerriero ,Peng Gao ,David R Soto-Pantoja ,Robert L Ferris ,Jennifer L Modliszewski ,Michael F Coleman ,H Kay Chung ,J Justin Milner ,Stergios J Moschos ,R Luke Wiseman ,Jessica E Thaxton

Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

增强子驱动的基因调控网络揭示了肿瘤微环境中调控T细胞适应和分化的转录因子

William D Green ,Amber Gomez ,Alec L Plotkin ,Brandon M Pratt ,Emily F Merritt ,Genevieve N Mullins ,Nancy P Kren ,Jennifer L Modliszewski ,Vasyl Zhabotynsky ,Mark G Woodcock ,Jarred M Green ,Gabrielle Cannon ,Matthew E Pipkin ,Gianpietro Dotti ,Jessica E Thaxton ,Yuliya Pylayeva-Gupta ,Albert S Baldwin ,John P Morris 4th ,Natalie Stanley ,J Justin Milner

Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain

通过绘制DNA甲基化图谱来识别人类创伤后应激障碍大脑皮层下区域的表观遗传变异

Hongyu Li,Yujing Liu,Yiming Shi,Jiawei Wang,Tuan P Nguyen,Yuhan Xie,Wangjie Zheng,Youshu Cheng,Dianne A Cruz,Jennifer L Modliszewski,Rosemarie Terwilliger,Alexa-Nicole Sliby,José Jaime Martínez-Magaña,Janitza L Montalvo-Ortiz,John D Roache,Lynnette A Averill,Stacey Young-McCaughan,Paulo R Shiroma,Bertrand R Huber,David A Lewis,Jill Glausier,Paul Holtzheimer,Matthew J Friedman,Jing Zhang,Alan L Peterson,Chadi G Abdallah,Amir Valizadeh,Xinyu Zhang,Ke Xu,John H Krystal,Ronald S Duman,Hongyu Zhao,David L Corcoran,Douglas E Williamson,Matthew J Girgenti

Enhancing radiotherapy response via intratumoral injection of a TLR9 agonist in autochthonous murine sarcomas

通过肿瘤内注射 TLR9 激动剂增强小鼠原发性肉瘤的放射治疗反应

Chang Su, Collin L Kent, Matthew Pierpoint, Warren Floyd, Lixia Luo, Nerissa T Williams, Yan Ma, Brian Peng, Alexander L Lazarides, Ajay Subramanian, Jonathon E Himes, Vincent M Perez, Rosa D Hernansaiz-Ballesteros, Kimberly E Roche, Jennifer L Modliszewski, Sara R Selitsky, Mari L Shinohara, Amy J

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

通过肿瘤内注射 TLR9 激动剂 CpG 来刺激原发性小鼠肉瘤模型中的 CD8 T 细胞,从而增强放射治疗反应

Chang Su, Collin L Kent, Matthew Pierpoint, Warren Floyd, Lixia Luo, Nerissa T Wiliams, Yan Ma, Brian Peng, Alexander L Lazarides, Ajay Subramanian, Jonathan E Himes, Vincent M Perez, Rosa D Hernansaiz-Ballesteros, Kimberly E Roche, Jennifer L Modliszewski, Sara R Selitsky, Mari Shinohara, Amy J Wis

CSNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling

CSNK2B 调节 IRF1 与功能性 DNA 元素的结合并促进基础和激动剂诱导的抗病毒信号传导

Moe Matsumoto, Jennifer L Modliszewski, Kotomi Shinozaki, Reona Maezawa, Vincent M Perez, Yuki Ishikawa, Ryosuke Suzuki, Kevin L McKnight, Takahiro Masaki, Asuka Hirai-Yuki, Michinori Kohara, Stanley M Lemon, Sara R Selitsky, Daisuke Yamane

Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

新辅助放射治疗和手术比单纯手术更能提高软组织肉瘤原发性小鼠模型的无转移生存率

Rutulkumar Patel #, Yvonne M Mowery #, Yi Qi, Alex M Bassil, Matt Holbrook, Eric S Xu, Cierra S Hong, Jonathon E Himes, Nerissa T Williams, Jeffrey Everitt, Yan Ma, Lixia Luo, Sara R Selitsky, Jennifer L Modliszewski, Junheng Gao, Sin-Ho Jung, David G Kirsch, Cristian T Badea

Temporary Knockdown of p53 During Focal Limb Irradiation Increases the Development of Sarcomas

局部肢体照射期间暂时抑制 p53 可增加肉瘤的发展

Andrea R Daniel, Chang Su, Nerissa T Williams, Zhiguo Li, Jianguo Huang, Omar Lopez, Lixia Luo, Yan Ma, Lorraine da Silva Campos, Sara R Selitsky, Jennifer L Modliszewski, Siyao Liu, Rosa Hernansaiz-Ballesteros, Yvonne M Mowery, Diana M Cardona, Chang-Lung Lee, David G Kirsch

Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions

鼠伤寒沙门氏菌甲基化组和转录组的整合表明,在毒力相关条件下,DNA 甲基化和转录调控在很大程度上是分离的

Jeffrey S Bourgeois, Caroline E Anderson, Liuyang Wang, Jennifer L Modliszewski, Wei Chen, Benjamin H Schott, Nicolas Devos, Dennis C Ko