日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening

通过全面的功能筛查确定 HCV E1E2 的脆弱位点

Jennifer M Pfaff-Kilgore, Edgar Davidson, Kathryn Kadash-Edmondson, Mayda Hernandez, Erin Rosenberg, Ross Chambers, Matteo Castelli, Nicola Clementi, Nicasio Mancini, Justin R Bailey, James E Crowe Jr, Mansun Law, Benjamin J Doranz

Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes

登革热疫苗在恒河猴中诱发的强效中和抗体针对不同的表位

Leike Li, Weixu Meng, Melanie Horton, Daniel R DiStefano, Elizabeth A Thoryk, Jennifer M Pfaff, Qihui Wang, Georgina T Salazar, Trevor Barnes, Benjamin J Doranz, Andrew J Bett, Danilo R Casimiro, Kalpit A Vora, Zhiqiang An, Ningyan Zhang

Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance

广泛中和抗体,几乎没有体细胞突变,可清除丙型肝炎病毒

Justin R Bailey, Andrew I Flyak, Valerie J Cohen, Hui Li, Lisa N Wasilewski, Anna E Snider, Shuyi Wang, Gerald H Learn, Nurgun Kose, Leah Loerinc, Rebecca Lampley, Andrea L Cox, Jennifer M Pfaff, Benjamin J Doranz, George M Shaw, Stuart C Ray, James E Crowe Jr

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

通过高通量诱变探索丙型肝炎病毒包膜糖蛋白复合物的抗原性

Radhika Gopal, Kelli Jackson, Netanel Tzarum, Leopold Kong, Andrew Ettenger, Johnathan Guest, Jennifer M Pfaff, Trevor Barnes, Andrew Honda, Erick Giang, Edgar Davidson, Ian A Wilson, Benjamin J Doranz, Mansun Law

Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1

将登革热病毒血清型 3 (DENV3) 特异性人单克隆抗体表位功能性移植到 DENV1 中

William B Messer, Boyd L Yount, Scott R Royal, Ruklanthi de Alwis, Douglas G Widman, Scott A Smith, James E Crowe Jr, Jennifer M Pfaff, Kristen M Kahle, Benjamin J Doranz, Kristie D Ibarra, Eva Harris, Aravinda M de Silva, Ralph S Baric

Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site

具有病毒复制增强特性的登革热病毒 prM 特异性人类单克隆抗体可识别单个免疫显性抗原位点

Scott A Smith, Usha K Nivarthi, Ruklanthi de Alwis, Nurgun Kose, Gopal Sapparapu, Robin Bombardi, Kristen M Kahle, Jennifer M Pfaff, Sherri Lieberman, Benjamin J Doranz, Aravinda M de Silva, James E Crowe Jr

Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity

登革热病毒包膜蛋白结构域 I/II 铰链决定长效血清型特异性登革热免疫力

William B Messer, Ruklanthi de Alwis, Boyd L Yount, Scott R Royal, Jeremy P Huynh, Scott A Smith, James E Crowe Jr, Benjamin J Doranz, Kristen M Kahle, Jennifer M Pfaff, Laura J White, Carlos A Sariol, Aravinda M de Silva, Ralph S Baric

The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein

强效且广泛中和的人类登革热病毒特异性单克隆抗体 1C19 在包膜蛋白结构域 II 的 bc 环上显示出独特的交叉反应表位

Scott A Smith, A Ruklanthi de Alwis, Nurgun Kose, Eva Harris, Kristie D Ibarra, Kristen M Kahle, Jennifer M Pfaff, Xiaoxiao Xiang, Benjamin J Doranz, Aravinda M de Silva, S Kyle Austin, Soila Sukupolvi-Petty, Michael S Diamond, James E Crowe Jr

Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7

传播/创始和慢性 C 亚型 HIV-1 使用 CD4 和 CCR5 受体的效率相同,并且不会通过阻断整合素 α4β7 来抑制

Nicholas F Parrish, Craig B Wilen, Lauren B Banks, Shilpa S Iyer, Jennifer M Pfaff, Jesus F Salazar-Gonzalez, Maria G Salazar, Julie M Decker, Erica H Parrish, Anna Berg, Jennifer Hopper, Bhavna Hora, Amit Kumar, Tatenda Mahlokozera, Sally Yuan, Charl Coleman, Marion Vermeulen, Haitao Ding, Christin

Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins

亚型传播/创始和慢性 HIV-1 包膜糖蛋白的表型和免疫学比较

Craig B Wilen, Nicholas F Parrish, Jennifer M Pfaff, Julie M Decker, Elizabeth A Henning, Hillel Haim, Josiah E Petersen, Jason A Wojcechowskyj, Joseph Sodroski, Barton F Haynes, David C Montefiori, John C Tilton, George M Shaw, Beatrice H Hahn, Robert W Doms