日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of ligand-receptor pairs that drive human astrocyte development

鉴定驱动人类星形胶质细胞发育的配体-受体对

Anna J Voss # ,Samantha N Lanjewar # ,Maureen M Sampson ,Alexia King ,Emily J Hill ,Anson Sing ,Caitlin Sojka ,Tarun N Bhatia ,Jennifer M Spangle ,Steven A Sloan

Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs

脂肪细胞介导的人类T细胞急性淋巴细胞白血病(T-ALL)细胞表观基因组不稳定性具有细胞毒性,并且可被表观遗传修饰药物模拟。

Miyoung Lee ,Delaney K Geitgey ,Jamie A G Hamilton ,Jeremy M Boss ,Christopher D Scharer ,Jennifer M Spangle ,Karmella A Haynes ,Curtis J Henry

Targeting MLL Methyltransferases Enhances the Antitumor Effects of PI3K Inhibition in Hormone Receptor-positive Breast Cancer

靶向 MLL 甲基转移酶可增强 PI3K 抑制在激素受体阳性乳腺癌中的抗肿瘤作用

Robert B Jones #, Jonathan Farhi #, Miranda Adams, Kiran K Parwani, Garrett W Cooper, Milica Zecevic, Richard S Lee, Andrew L Hong, Jennifer M Spangle

A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations

酿酒酵母模型和筛选以确定致癌组蛋白错义突变的功能后果

Laramie D Lemon, Sneha Kannan, Kim Wai Mo, Miranda Adams, Haley G Choi, Alexander O D Gulka, Elise S Withers, Hasset T Nurelegne, Valeria Gomez, Reina E Ambrocio, Rhea Tumminkatti, Richard S Lee, Morris Wan, Milo B Fasken, Jennifer M Spangle, Anita H Corbett

PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition

PIK3CA C 端移码突变是新的致癌事件,可使肿瘤对 PI3K-α 抑制敏感

Jennifer M Spangle, Thanh Von, Dean C Pavlick, Arina Khotimsky, Jean J Zhao, Thomas M Roberts

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α

PI3K-p110α 介导新型肿瘤抑制因子 PI3K-p85α 缺失引起的致癌活性

Lauren M Thorpe, Jennifer M Spangle, Carolynn E Ohlson, Hailing Cheng, Thomas M Roberts, Lewis C Cantley, Jean J Zhao

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

PI3K/AKT 信号调节乳腺癌中的 H3K4 甲基化

Jennifer M Spangle, Koen M Dreijerink, Anna C Groner, Hailing Cheng, Carolynn E Ohlson, Jaime Reyes, Charles Y Lin, James Bradner, Jean J Zhao, Thomas M Roberts, Myles Brown

The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species

HPV16 E6 癌蛋白可引起受体蛋白酪氨酸激酶信号传导延长,并增强磷酸化受体物质的内化

Jennifer M Spangle, Karl Munger

Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif

粘膜人乳头瘤病毒 E6 蛋白激活帽子依赖性翻译依赖于 LXXLL 结合基序的完整性

Jennifer M Spangle, Nayana Ghosh-Choudhury, Karl Munger

The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis

人类乳头瘤病毒 16 型 E6 癌蛋白可激活 mTORC1 信号并增加蛋白质合成

Jennifer M Spangle, Karl Münger