Gain-of-function mutation in SKAP2 leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cells
SKAP2基因的功能获得性突变会导致1型糖尿病，并通过髓系细胞中整合素信号传导过度激活引发更广泛的自身免疫性疾病。
期刊:
影响因子:
doi:10.64898/2026.04.02.716136
Tamaki, Courtney M; Chamberlain, Chester E; Abram, Clare L; Poojary, Sumith; Bridge, Jennifer; Matsuda, Jennifer L; Tamaki, Whitney; Rutsch, Niklas; Spector, Lauren; Dixon, Wesley; Proekt, Irina; Letourneau-Freiberg, Lisa R; Philipson, Louis H; German, Michael S; Anderson, Mark S; Lowell, Clifford A
信号转导
自身免疫性疾病
代谢
糖尿病
细胞生物学
免疫/内分泌
