Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling.
MS-275 通过 Akt/ARK5-FoxO 和肌肉生长抑制素-Smad 信号通路抑制 I 类组蛋白去乙酰化酶的表观遗传作用，从而减轻糖尿病骨骼肌萎缩。
期刊:Frontiers in Endocrinology
影响因子:4.6
doi:10.3389/fendo.2026.1788603
Son Youngho, Byeon Hye-Eun, Choi Sung-E, Kim Youngha, Heo Yu Jung, Kwon Soon Beom, Choi Jaemyung, Han Seung Jin, Jeon Jayoung, Kim Hae Jin, Lee Nami, Lee Kwan-Woo
