TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease.
TM4SF5介导的肝细胞KEAP1调控与NRF2表达和活性无关,促进氧化应激和炎症,从而发展为代谢功能障碍相关的脂肪肝疾病。
期刊:International Journal of Biological Sciences
影响因子:10
doi:10.7150/ijbs.126251
Shin Eun-Ae, Lee Haesong, Pyo Kyung-Hee, Kim Wonsik, Kim Soyeon, Lee Jae-Ho, Jin Seo Hee, Kim Eunmi, Byeon Soo-Min, Kim Dong Joo, Cho Young Jun, Kim Tae Won, Ohn Minjae, Lee Hyojung, Lee Jeongwon, Jeong Jinwook, Kim Doojin, Zheng Jie, Lee Han Ah, Kim Hwi Young, Surh Young-Joon, Lee Jung Weon
KEAP1
炎症
氧化应激
炎症/感染
信号转导
Immunology/Inflammation
代谢
NRF2
脂肪肝
细胞生物学
毒理研究