日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The insect pathogenic bacterium Xenorhabdus innexi has attenuated virulence in multiple insect model hosts yet encodes a potent mosquitocidal toxin

昆虫病原菌 Xenorhabdus innexi 在多种昆虫模型宿主中毒力减弱,但编码了一种强效的杀蚊毒素

Il-Hwan Kim, Sudarshan K Aryal, Dariush T Aghai, Ángel M Casanova-Torres, Kai Hillman, Michael P Kozuch, Erin J Mans, Terra J Mauer, Jean-Claude Ogier, Jerald C Ensign, Sophie Gaudriault, Walter G Goodman, Heidi Goodrich-Blair, Adler R Dillman

A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs

一项评估气溶胶递送 AERAS-402/Ad35 疫苗的非人灵长类动物毒理学和免疫原性研究:外周血中短暂的 T 细胞反应和肺部强烈的持续反应的证据

Hokey, David A; Wachholder, Robert; Darrah, Patricia A; Bolton, Diane L; Barouch, Dan H; Hill, Krystal; Dheenadhayalan, Veerabadran; Schwander, Stephan; Godin, C Steven; Douoguih, Macaya; Pau, Maria Grazia; Seder, Robert A; Roederer, Mario; Sadoff, Jerald C; Sizemore, Donata

Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge

用AERAS-402进行气溶胶疫苗接种可在恒河猴肺部诱导强烈的细胞免疫反应,但无法抵御高剂量结核分枝杆菌的攻击。

Darrah, Patricia A; Bolton, Diane L; Lackner, Andrew A; Kaushal, Deepak; Aye, Pyone Pyone; Mehra, Smriti; Blanchard, James L; Didier, Peter J; Roy, Chad J; Rao, Srinivas S; Hokey, David A; Scanga, Charles A; Sizemore, Donata R; Sadoff, Jerald C; Roederer, Mario; Seder, Robert A

Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults

新型结核病疫苗M72/AS01在南非成年人中诱导和调节T细胞免疫

Day, Cheryl L; Tameris, Michele; Mansoor, Nazma; van Rooyen, Michele; de Kock, Marwou; Geldenhuys, Hennie; Erasmus, Mzwandile; Makhethe, Lebohang; Hughes, E Jane; Gelderbloem, Sebastian; Bollaerts, Anne; Bourguignon, Patricia; Cohen, Joe; Demoitié, Marie-Ange; Mettens, Pascal; Moris, Philippe; Sadoff, Jerald C; Hawkridge, Anthony; Hussey, Gregory D; Mahomed, Hassan; Ofori-Anyinam, Opokua; Hanekom, Willem A

The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults

新型结核病疫苗AERAS-402可在成人体内诱导产生强效且多功能的CD4+和CD8+ T细胞。

Abel, Brian; Tameris, Michele; Mansoor, Nazma; Gelderbloem, Sebastian; Hughes, Jane; Abrahams, Deborah; Makhethe, Lebohang; Erasmus, Mzwandile; de Kock, Marwou; van der Merwe, Linda; Hawkridge, Anthony; Veldsman, Ashley; Hatherill, Mark; Schirru, Giulia; Pau, Maria Grazia; Hendriks, Jenny; Weverling, Gerrit Jan; Goudsmit, Jaap; Sizemore, Donata; McClain, J Bruce; Goetz, Margaret; Gearhart, Jacqueline; Mahomed, Hassan; Hussey, Gregory D; Sadoff, Jerald C; Hanekom, Willem A

Genetic immunization in the lung induces potent local and systemic immune responses

肺部基因免疫可诱导强烈的局部和全身免疫反应。

Song, Kaimei; Bolton, Diane L; Wei, Chih-Jen; Wilson, Robert L; Camp, Jeremy V; Bao, Saran; Mattapallil, Joseph J; Herzenberg, Leonore A; Herzenberg, Leonard A; Andrews, Charla A; Sadoff, Jerald C; Goudsmit, Jaap; Pau, Maria Grazia; Seder, Robert A; Kozlowski, Pamela A; Nabel, Gary J; Roederer, Mario; Rao, Srinivas S

Novel recombinant Mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus Ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques

新型重组牛分枝杆菌 BCG、绵羊腺病毒和改良痘苗病毒安卡拉疫苗联合使用可在恒河猴中诱导强大的人类免疫缺陷病毒特异性 CD4 和 CD8 T 细胞反应

Maximillian Rosario, Richard Hopkins, John Fulkerson, Nicola Borthwick, Máire F Quigley, Joan Joseph, Daniel C Douek, Hui Yee Greenaway, Vanessa Venturi, Emma Gostick, David A Price, Gerald W Both, Jerald C Sadoff, Tomás Hanke

Safety and immunogenicity of novel recombinant BCG and modified vaccinia virus Ankara vaccines in neonate rhesus macaques

新型重组卡介苗和改良型安卡拉痘苗病毒疫苗在新生恒河猴中的安全性和免疫原性

Rosario, Maximillian; Fulkerson, John; Soneji, Shamit; Parker, Joe; Im, Eung-Jun; Borthwick, Nicola; Bridgeman, Anne; Bourne, Charles; Joseph, Joan; Sadoff, Jerald C; Hanke, Tomás

Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses

通过综合数据挖掘和生物信息学分析对结核分枝杆菌疫苗候选菌株进行全基因组鉴定

Zvi, Anat; Ariel, Naomi; Fulkerson, John; Sadoff, Jerald C; Shafferman, Avigdor

Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon

两种小鼠品系对重组腺病毒35型结核病疫苗的保护性免疫反应:CD4和CD8 T细胞表位定位及γ干扰素的作用

Radosevic, Katarina; Wieland, Catharina W; Rodriguez, Ariane; Weverling, Gerrit Jan; Mintardjo, Ratna; Gillissen, Gert; Vogels, Ronald; Skeiky, Yasir A W; Hone, David M; Sadoff, Jerald C; van der Poll, Tom; Havenga, Menzo; Goudsmit, Jaap