日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities.

脑源性 tau 寡聚体多晶型:不同的聚集体、稳定性特征和生物活性

Lo Cascio Filippa, Park Suhyeorn, Sengupta Urmi, Puangmalai Nicha, Bhatt Nemil, Shchankin Nikita, Jerez Cynthia, Moreno Naomi, Bittar Alice, Xavier Rhea, Zhao Yingxin, Wang Cankun, Fu Hongjun, Ma Qin, Montalbano Mauro, Kayed Rakez

Characterization of conformation-specific antibodies TOMA-1 and TTCM-1 for recombinant tau monomer and amplified brain derived tau oligomer

对重组tau单体和扩增的脑源性tau寡聚体的构象特异性抗体TOMA-1和TTCM-1进行表征

Haque, Md Anzarul; Montalbano, Mauro; Khan, Sheeza; Puangmalai, Nicha; Bhatt, Nemil; Shchankin, Nikita; Jerez, Cynthia; Kayed, Rakez

Generation of nanobodies with conformational specificity for tau oligomers that recognize tau aggregates from human Alzheimer's disease samples

生成对tau寡聚体具有构象特异性的纳米抗体,该纳米抗体可识别来自人类阿尔茨海默病样本的tau聚集体

McArthur, Nikki; Squire, Jay D; Onyeachonam, Ogechukwu J; Bhatt, Nemil N; Jerez, Cynthia; Holberton, Abigail L; Tessier, Peter M; Wood, Levi B; Kayed, Rakez; Kane, Ravi S

C9orf72-associated dipeptide protein repeats form A11-positive oligomers in amyotrophic lateral sclerosis and frontotemporal dementia

C9orf72相关二肽蛋白重复序列在肌萎缩侧索硬化症和额颞叶痴呆中形成A11阳性寡聚体

Bhatt, Nemil; Puangmalai, Nicha; Sengupta, Urmi; Jerez, Cynthia; Kidd, Madison; Gandhi, Shailee; Kayed, Rakez

Toxic Interplay Between Small Dipeptide Protein Repeats and Tau in Tauopathies

小二肽蛋白重复序列与Tau蛋白在Tau蛋白病中的毒性相互作用

Havelaar, Arie H; van Rosse, Floor; Bucura, Catalin; Toetenel, Milou A; Haagsma, Juanita A; Kurowicka, Dorota; Heesterbeek, J Hans A P; Speybroeck, Niko; Langelaar, Merel F M; van der Giessen, Johanna W B; Cooke, Roger M; Braks, Marieta A H; Bhatt, Nemil; Puangmalai, Nicha; Jerez, Cynthia; Shchankin, Nikita; Kayed, Rakez

Nuclear HMGB1 Loss in the Aging Brain Triggers cGAS‐STING Pathway and Neuroinflammation that Contributes to Senescence and Cognitive Decline in Tauopathies

衰老大脑中核内HMGB1的丢失会触发cGAS-STING通路和神经炎症,从而导致tau蛋白病患者的衰老和认知能力下降。

Poh, Xue Wei Wendy; Lim, Shernice Shi Yun; Chew, Ying Yin; Lim-Ashworth, Nikki Shi Jie; Lim, Choon Guan; Gaikwad, Sagar; Haque, Md Anzarul; Samples, Madison; Xavier, Rhea; Jerez, Cynthia; Al‐Shaebi, Fadhl; Kayed, Rakez

Nuclear HMGB1 Loss in the Aging Brain Triggers cGAS‐STING Pathway and Neuroinflammation that Contributes to Senescence and Cognitive Decline in Tauopathies

衰老大脑中核内HMGB1的丢失会触发cGAS-STING通路和神经炎症,从而导致tau蛋白病患者的衰老和认知能力下降。

Wu, Henry H L; Shenoy, Mohan; Kalra, Philip A; Chinnadurai, Rajkumar; Gaikwad, Sagar; Haque, Md Anzarul; Samples, Madison; Xavier, Rhea; Jerez, Cynthia; Al‐Shaebi, Fadhl; Kayed, Rakez

COMPARISON OF STEREOLOGY METHODS FOR ASSESSING AGE-RELATED EFFECTS ON IMMUNOSTAINED BRAIN CELLS

比较立体学方法在评估年龄相关效应对免疫染色脑细胞的影响方面的差异

Solorzano, Alexander; Brady, Molly; Bhatt, Nemil; Johnson, Angelique; Burgess, Brooke; Leyva, Hannah; Puangmalai, Nicha; Jerez, Cynthia; Wood, Ronald; Kayed, Rakez; Deane, Rashid; O’Sullivan, Carly L; Tyreman, Neil; Shanti, Rofyontsa F; O’Steen, Wilbur A; Mirkiani, Soroush; Boakye, Maxwell; Howland, Dena R; Mushahwar, Vivian K; Denham, Grant; Alahmari, Saeed; Anderson, Aidan; Sanchez, Krystal; Dag, Dominick; Hall, Lawrence; Goldgof, Dmitry; Mouton, Peter

Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils

利用流式细胞术分离针对淀粉样原纤维的类药物构象抗体

Desai, Alec A; Zupancic, Jennifer M; Trzeciakiewicz, Hanna; Gerson, Julia E; DuBois, Kelly N; Skinner, Mary E; Sharkey, Lisa M; McArthur, Nikki; Ferris, Sean P; Bhatt, Nemil N; Makowski, Emily K; Smith, Matthew D; Chen, Hongwei; Huang, Jie; Jerez, Cynthia; Kane, Ravi S; Kanaan, Nicholas M; Paulson, Henry L; Tessier, Peter M