日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon-like peptide-1 and glucagon receptor in healthy subjects

一项旨在探索健康受试者体内胰高血糖素样肽-1和胰高血糖素受体双重激动剂对血液动力学影响的实验医学方案

Goodman, James; Parker, Victoria E; McEniery, Carmel M; Di Stefano, Giovanni; Hubsch, Annette; Vamvaka, Evangelia; Helmy, Jo; Kaloyirou, Fotini; Jalaludeen, Navazh; Barker, Peter; Jermutus, Lutz; Cheriyan, Joseph; Ambery, Philip; Wilkinson, Ian B

A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction.

一种新型长效松弛素-2融合蛋白AZD3427可改善患有心脏功能障碍的非人灵长类动物的心脏功能

Papworth Monika, Kulkarni Spoorthy, Antonsson Madeleine, Sermadiras Isabelle, Hovdal Daniel, Connolly Kathleen, Olsson Jan, Shukla Animesh, Cotton Peter, Althage Magnus, Paterson Judy, Martin Esther, Wolny Marcin, Ferraro Franco, Sadowska Agnieszka, Hao Weidong, Larsson Niklas, Backmark Anna, Marlow Tom, Perez Rosario, Jermutus Lutz, Omar Sami, George Richard T, Gabrielsen Anders, Pettersen Daniel, Jennbacken Karin

Exenatide and glucagon co-infusion increases myocardial glucose uptake and improves markers of diastolic dysfunction in adults with type 2 diabetes

艾塞那肽和胰高血糖素联合输注可增加心肌葡萄糖摄取,并改善2型糖尿病成人患者的舒张功能障碍指标。

Goodman, James; Schain, Martin; Di Stefano, Giovanni; Lupson, Victoria; Horn, Tracy; Hill, Marion; Manavaki, Roie; Fryer, Timothy D; Bumanlag-Amis, Elaine; Jalaludeen, Navazh; Jermutus, Lutz; Johansson, Edvin; Heurling, Kerstin; Haraldsson, Henrik; Evans, Mark; Cheriyan, Joseph; Johansson, Lars; Ambery, Philip; Wilkinson, Ian B

Design and rationale for a global novel non-invasive screening observational study using genetics and non-invasive methodologies to identify at-risk MASLD participants: The ALIGN study

一项利用遗传学和非侵入性方法识别高危MASLD患者的全球新型非侵入性筛查观察性研究的设计和原理:ALIGN研究

Daniels, Samuel J; Nelander, Karin; Eriksson, John; Jermutus, Lutz; Saillard, Jelena; Oyesola, Stephanie; Tavaglione, Federica; Arrese, Marco; Ladrón de Guevara, Alma Laura; Vespasiani-Gentilucci, Umberto; Alkhouri, Naim; Blau, Jenny E

The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk

双重GLP-1/胰高血糖素受体激动剂G49通过诱导代谢重编程和器官间相互作用来模拟减肥手术的效果。

Valdecantos, M Pilar; Ruiz, Laura; Folgueira, Cintia; Rada, Patricia; Gomez-Santos, Beatriz; Solas, Maite; Hitos, Ana B; Field, Joss; Francisco, Vera; Escalona-Garrido, Carmen; Zagmutt, Sebastián; Calderon-Dominguez, María; Mera, Paula; Garcia-Martinez, Irma; Maymó-Masip, Elsa; Grajales, Diana; Alen, Rosa; Mora, Alfonso; Sáinz, Neira; Vides-Urrestarazu, Irene; Vilarrasa, Nuria; Arbones-Mainar, José M; Zaragoza, Carlos; Moreno-Aliaga, María J; Aspichueta, Patricia; Fernández-Veledo, Sonia; Vendrell, Joan; Serra, Dolors; Herrero, Laura; Schreiber, Renate; Zechner, Rudolf; Sabio, Guadalupe; Hornigold, David; Rondinone, Cristina M; Jermutus, Lutz; Grimsby, Joseph; Valverde, Ángela M

Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

通过α2-巨球蛋白介导的共价捕获实现蛋白酶激活和特异性的进化

Philipp Knyphausen ,Mariana Rangel Pereira ,Paul Brear ,Marko Hyvönen ,Lutz Jermutus ,Florian Hollfelder

Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart

胰高血糖素和艾塞那肽可改善离体灌注大鼠心脏缺血/再灌注后的收缩功能恢复。

Lindsay, Ross T; Ambery, Philip; Jermutus, Lutz; Murray, Andrew J

Exploiting protease activation for therapy

利用蛋白酶激活进行治疗

Bleuez, Chloe; Koch, Wolfgang F; Urbach, Carole; Hollfelder, Florian; Jermutus, Lutz

Efficacy and safety of cotadutide, a dual glucagon-like peptide-1 and glucagon receptor agonist, in a randomized phase 2a study of patients with type 2 diabetes and chronic kidney disease

一项针对2型糖尿病合并慢性肾病患者的随机2a期研究评估了双重胰高血糖素样肽-1和胰高血糖素受体激动剂cotadutide的疗效和安全性。

Parker, Victoria E R; Hoang, Thuong; Schlichthaar, Heike; Gibb, Fraser W; Wenzel, Barbara; Posch, Maximillian G; Rose, Ludger; Chang, Yi-Ting; Petrone, Marcella; Hansen, Lars; Ambery, Philip; Jermutus, Lutz; Heerspink, Hiddo J L; McCrimmon, Rory J

The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1

人类和小鼠胰岛肽组:肥胖和 2 型糖尿病的影响,以及胰岛内胰高血糖素样肽-1 产生的评估

Sam G Galvin, Richard G Kay, Rachel Foreman, Pierre Larraufie, Claire L Meek, Emma Biggs, Peter Ravn, Lutz Jermutus, Frank Reimann, Fiona M Gribble