Jernberg-Wiklund相关文献与解析，生知库 | 链接生命科学的每一步

Patrick Nylund ，Berta Garrido-Zabala ，Stefania Iliana Tziola ，Tabassom Mohajershojai ，Hanna Berglund ，Catharina Muylaert ，Lien Ann Van Hemelrijck ，Alba Atienza Párraga ，Louella Vasquez ，Jim Jacob ，Eric Bergquist ，José Ignacio Martín-Subero ，Fredrik Öberg ，Torbjörn Karlsson ，Marika Nestor ，Elke De Bruyne ，Antonia Kalushkova ，Helena Jernberg Wiklund

肿瘤

骨髓瘤

T细胞

发表日期：2025

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Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

组合式DNMTs和EZH2抑制可重编程H3K27me3和DNAme介导的癌基因表观基因组，从而抑制多发性骨髓瘤增殖。

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-025-17093-z

Alba Atienza Párraga #,Patrick Nylund #,Klev Diamanti,Berta Garrido-Zabala,Stefania Iliana Tziola,Louella Vasquez,Paul Theodor Pyl,Doroteya Raykova,Aron Skaftason,Anqi Ma,Jian Jin,José Ignacio Martín-Subero,Fredrik Öberg,Elke De Bruyne,Jan Komorowski,Helena Jernberg Wiklund,Antonia Kalushkova

PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

PVT1 与多梳抑制复合物 2 相互作用，抑制多发性骨髓瘤中具有促凋亡和肿瘤抑制功能的基因组区域

期刊:Haematologica

影响因子:8.2

doi:10.3324/haematol.2023.282965

Patrick Nylund, Berta Garrido-Zabala, Alba Atienza Párraga, Louella Vasquez, Paul Theodor Pyl, George Mickhael Harinck, Anqi Ma, Jian Jin, Fredrik Öberg, Antonia Kalushkova, Helena Jernberg Wiklund

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

多发性骨髓瘤对 EZH2 抑制剂的敏感性具有独特的代谢反应特征。

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-021-03447-8

Patrick Nylund # ，Alba Atienza Párraga # ，Jakob Haglöf ，Elke De Bruyne ，Eline Menu ，Berta Garrido-Zabala ，Anqi Ma ，Jian Jin ，Fredrik Öberg ，Karin Vanderkerken ，Antonia Kalushkova ，Helena Jernberg-Wiklund

One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies

单一的组学方法并不能包治百病：代谢组和表观基因组在血液系统恶性肿瘤中协同作用

期刊:Epigenomes

影响因子:3.5

doi:10.3390/epigenomes5040022

Kalushkova, Antonia; Nylund, Patrick; Párraga, Alba Atienza; Lennartsson, Andreas; Jernberg-Wiklund, Helena

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

针对 4-1BB 和/或 CD40 的免疫刺激性溶瘤病毒疗法治疗多发性骨髓瘤

期刊:Cancer Gene Therapy

影响因子:4.8

doi:10.1038/s41417-020-0176-9

Jessica Wenthe ，Sedigheh Naseri ，Ann-Charlotte Hellström ，Helena Jernberg Wiklund ，Emma Eriksson ，Angelica Loskog

Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity

靶向 EZH2 治疗多发性骨髓瘤——多方面的抗肿瘤活性

期刊:Epigenomes

影响因子:3.5

doi:10.3390/epigenomes2030016

Alzrigat, Mohammad; Jernberg-Wiklund, Helena; Licht, Jonathan D

SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation

SUMO 修饰的胰岛素样生长因子 1 受体 (IGF-1R) 增加细胞周期进程和细胞增殖

期刊:Journal of Cellular Physiology

影响因子:4.5

doi:10.1002/jcp.25818

Yingbo Lin, Hongyu Liu, Ahmed Waraky, Felix Haglund, Prasoon Agarwal, Helena Jernberg-Wiklund, Dudi Warsito, Olle Larsson

The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma

miR-125a 和 miR-320c 是潜在的肿瘤抑制性 microRNA，在多发性骨髓瘤中被多梳抑制复合物 2 表观遗传沉默。

期刊:RNA DISEASE

影响因子:

doi:10.14800/rd.1529

Alzrigat, Mohammad; Jernberg-Wiklund, Helena

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions

多发性骨髓瘤中的 EZH2 抑制会下调骨髓瘤相关致癌基因并上调具有潜在肿瘤抑制功能的 microRNA

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.14378

Mohammad Alzrigat, Alba Atienza Párraga, Prasoon Agarwal, Hadil Zureigat, Anders Österborg, Hareth Nahi, Anqi Ma, Jian Jin, Kenneth Nilsson, Fredrik Öberg, Antonia Kalushkova, Helena Jernberg-Wiklund

Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

双重靶向G9a和DNMTs可诱导多发性骨髓瘤的抗肿瘤作用

Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

组合式DNMTs和EZH2抑制可重编程H3K27me3和DNAme介导的癌基因表观基因组，从而抑制多发性骨髓瘤增殖。

PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

PVT1 与多梳抑制复合物 2 相互作用，抑制多发性骨髓瘤中具有促凋亡和肿瘤抑制功能的基因组区域

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

多发性骨髓瘤对 EZH2 抑制剂的敏感性具有独特的代谢反应特征。

One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies

单一的组学方法并不能包治百病：代谢组和表观基因组在血液系统恶性肿瘤中协同作用

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

针对 4-1BB 和/或 CD40 的免疫刺激性溶瘤病毒疗法治疗多发性骨髓瘤

Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity

靶向 EZH2 治疗多发性骨髓瘤——多方面的抗肿瘤活性

SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation

SUMO 修饰的胰岛素样生长因子 1 受体 (IGF-1R) 增加细胞周期进程和细胞增殖

The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma

miR-125a 和 miR-320c 是潜在的肿瘤抑制性 microRNA，在多发性骨髓瘤中被多梳抑制复合物 2 表观遗传沉默。

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions

多发性骨髓瘤中的 EZH2 抑制会下调骨髓瘤相关致癌基因并上调具有潜在肿瘤抑制功能的 microRNA