日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)

选择性和中枢神经系统渗透性炔基TREK抑制剂的优化：ONO-9517601 (VU6022856) 和 ONO-7927846 (VU6024391) 的发现和表征

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02535
Tanaka, Motoyuki; Sekioka, Yoko; Hashimoto, Gakuji; Mori, Takahiro; Shono, Tomoyuki; Isaji, Yuuki; Hisaichi, Katsuya; Childress, Elizabeth S; Bollinger, Sean; Schmitt, Joza A; Chopko, Trevor C; Garrison, Aaron T; Perry, Charles K; Chronister, Keagan; Kramer, Meghan; Chang, Sichen; Watson, Katherine J; Dickerson, Jonathan W; Bubser, Michael; Rook, Jerri M; Jones, Carrie K; Boutaud, Olivier; Bridges, Thomas M; Denton, Jerod S; Engers, Darren W; Kurata, Haruto; Lindsley, Craig W
神经科学
发表日期：2025
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A conserved mechanism of LRRC8 channel inhibition by two structurally distinct drugs

两种结构不同的药物对LRRC8通道抑制的保守机制

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-08795-1
Yamada, Toshiki; Bisignano, Paola; Karakas, Erkan; Denton, Jerod S
发表日期：2025
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Automated patch clamp analysis of heterologously expressed Kir6.2/SUR1 and Kir6.1/SUR2B K(ATP) currents.

异源表达的 Kir6.2/SUR1 和 Kir6.1/SUR2B K(ATP) 电流的自动膜片钳分析

期刊:American Journal of Physiology-Cell Physiology
影响因子:4.7
doi:10.1152/ajpcell.00266.2025
Li Kangjun, Janve Vaishali Satpute, Denton Jerod S
发表日期：2025
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Kir5.1-modulated potassium flux stimulates an anabolic kidney phenotype

Kir5.1 调控的钾离子流刺激肾脏产生合成代谢表型

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2025.113601.
Aihua Wu ,Masa-Ki Inoue ,Yahua Zhang ,Clinton M Hasenour ,Juan Pablo Arroyo ,Fabian Bock ,Alina Yu ,Mohammed Z Ferdaus ,Yvette Blackwell ,Roman M Lazarenko ,Jamey D Young ,Jerod S Denton ,Eric Delpire ,Ming-Zhi Zhang ,Raymond C Harris ,Andrew S Terker
代谢
发表日期：2025
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Recent advances in structural characterization of volume-regulated anion channels (VRACs)

体积调节阴离子通道（VRAC）结构表征的最新进展

期刊:Journal of Physiology-London
影响因子:4.4
doi:10.1113/JP286189
Karakas, Erkan; Strange, Kevin; Denton, Jerod S
发表日期：2025
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Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel K(ir)2.1: Discovery of VU6080824

内向整流钾通道 K(ir)2.1 的下一代抑制剂的特性研究：VU6080824 的发现

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00297
Duncan, Renn A; Haymer, Daniel H; Lazarenko, Roman M; Li, Liangping; Blackwell, Yvette; Days, Emily L; Krishnan, Srinivasan; Gray, Analisa Thompson; Boutaud, Olivier; Engers, Darren W; Lindsley, Craig W; Denton, Jerod S; Bender, Aaron M
发表日期：2025
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Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound

ONO-TR-772 (VU6018042) 的发现：一种高选择性且能穿透中枢神经系统的 TREK 抑制剂体内工具化合物

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00215
Tanaka, Motoyuki; Mori, Takahiro; Hashimoto, Gakuji; Mitsui, Katsukuni; Kishi, Akihiro; Childress, Elizabeth S; Bollinger, Sean R; Chopko, Trevor C; Bridges, Thomas M; Stafford, Douglas G; Huang, Zhonping; Wolf, Mark A; Engers, Darren W; Denton, Jerod S; Kurata, Haruto; Lindsley, Craig W
神经科学
发表日期：2025
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Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound

ONO-2920632 (VU6011887) 的发现：一种高选择性且能穿透中枢神经系统的 TREK-2 (TWIK 相关钾离子通道 2) 优先激活剂的体内工具化合物

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.5c00032
Yashiro, Kentaro; Iwaki, Yuzo; Urata, Hirohito; Kokubo, Masaya; Mori, Takahiro; Sekioka, Yoko; Isami, Koichi; Kato, Junya; Wieting, Joshua; McGowan, Kevin M; Bridges, Thomas M; Boutaud, Olivier; Engers, Darren W; Denton, Jerod S; Kurata, Haruto; Lindsley, Craig W
神经科学
发表日期：2025
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Highly Potent and Subtype-Selective Sperm-Specific Potassium Channel SLO3 Inhibitors Display High Tissue Exposure in the Murine Female Reproductive Tract

高效且具有亚型选择性的精子特异性钾通道SLO3抑制剂在小鼠雌性生殖道中表现出高组织暴露量

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00416
Temple, Kayla J; Li, Ping; McKinnie, Hallie G; Thompson Gray, Analisa; Bertron, Jeanette L; Ringuette, Anna E; de Andrade Horn, Pedro; Lyon, Maximilian D; Bhagwat, Shweta; Asadi, Leila; Li, Sophia; Lazarenko, Roman M; McCarthy, Ronald; Chang, Sichen; Turkett, Jeremy A; Kramlinger, Valerie; Watson, Katherine J; Zagol-Ikapitte, Irene A; Denton, Jerod S; Santi, Celia M; Jones, Carrie K; Lindsley, Craig W; Boutaud, Olivier
发表日期：2025
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Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2

低钾激活近端 mTOR/AKT 信号由 Kir4.2 介导

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-49562-w
Yahua Zhang, Fabian Bock, Mohammed Ferdaus, Juan Pablo Arroyo, Kristie L Rose, Purvi Patel, Jerod S Denton, Eric Delpire, Alan M Weinstein, Ming-Zhi Zhang, Raymond C Harris, Andrew S Terker
信号转导
PI3K/Akt
mTOR
发表日期：2024
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