日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy

VU6025733 (AG06827) 的发现:一种高选择性、口服生物利用度高、结构独特的 M(4) 毒蕈碱乙酰胆碱受体正向变构调节剂 (PAM),具有强大的体内疗效

Gregro, Alison R; Park, Charlotte; Long, Madeline F; Baker, Logan A; Bollinger, Katrina A; Ringuette, Anna E; Peng, Li; Luscombe, Vincent B; Billard, Natasha B; Rodriguez, Alice L; Niswender, Colleen M; Peng, Weimin; Dickerson, Jonathan W; Rook, Jerri M; O'Neill, Jordan; Chang, Sichen; Boonen, Harrie C M; Jensen, Thomas; Thomsen, Morten S; Bridges, Thomas M; Boutaud, Olivier; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W; Temple, Kayla J

Discovery of 7-(Pyridin-3-yl)thieno[3,2-b]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

发现 7-(吡啶-3-基)噻吩并[3,2-b]吡啶-5-甲酰胺类化合物作为代谢型谷氨酸受体5亚型的负变构调节剂

Henderson, Scott H; Ringuette, Anna E; Whomble, David L; Capstick, Rory A; Richardson, Alexa E; Maurer, Mallory A; Billard, Natasha B; Lei, Xia; Wilkinson, Joshua C; Kethanapalli, Sri H; Cho, Hyekyung P; Rodriguez, Alice L; Niswender, Colleen M; Peng, Weimin; Rook, Jerri M; Chang, Sichen; Blobaum, Anna L; Boutaud, Olivier; Felts, Andrew S; Conn, P Jeffrey; Lindsley, Craig W; Temple, Kayla J

Clinically Significant Neuroimaging Findings Among Pediatric Patients Presenting to the Emergency Department With Symptoms of Psychosis: A Multicenter Retrospective Study

临床上具有重要意义的神经影像学发现:一项多中心回顾性研究,探讨了出现精神病症状的儿科患者在急诊科就诊时的表现。

Hoffmann, Jennifer A; Parikh, Tapan K; Lorenz, Doug; Goldman, Michael P; Powers, Emily M; Patel, Shilpa J; Lavina, Ilana S; Heyming, Theodore W; England, Jasmin T; Saidinejad, Mohsen; Claudius, Ilene; Ghosh, Pallavi; Shapiro, Daniel J; Swan, Tricia B; Bouvay, Kamali L; Kurowski, Eileen Murtagh; Smith, Nadine M; Davis, Justin R; Moxam, Alexander B; Muhrer, Eli J; Shenoi, Rohit P; Portillo, Elyse N; Kaplan, Ron L; Uspal, Neil G; Lapus, Robert M; Vo, Andrea T; Fenster, Daniel B; Barrocas, Danielle B; Liu, Deborah R; Chaudhari, Pradip P; Cafferty, Rachel; Freedman, Stephen B; Rose, Jerri A; Evers, Megan F; Metcalf, Ashley M; Saleh, Fareed; Dunnick, Jennifer; Pitetti, Raymond D; Nathani, Yashas R; Waseem, Muhammad; Florin, Todd A

The influence of peer navigators on intervention adherence and retention among older adults: A study within a randomized trial - SWAT

同伴导航员对老年人干预依从性和保持率的影响:一项随机试验中的研究 - SWAT

Runge, Shannon K; Hudak, Elizabeth M; Sutfin, Jade A; Dobrovolskiy, Victor R; Edwards, Jerri D

The L-lactate dehydrogenase LldD contributes to oxidative stress resistance, survival from neutrophils, and host colonization in Neisseria gonorrhoeae

L-乳酸脱氢酶LldD有助于淋病奈瑟菌抵抗氧化应激、从嗜中性粒细胞中存活以及在宿主中定植。

Lankford, Jerri M; Barr, Willis E; Andersen, Cole A; Karuppiah, Amitha A; Thomas, Keena S; Glomski, Ian J; Huang, Wen-Chi; Criss, Alison K; Potter, Aimee D

Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M(1) positive allosteric modulator VU0467319 for Alzheimer's disease: a single ascending-dose study in healthy participants

毒蕈碱M(1)正向变构调节剂VU0467319治疗阿尔茨海默病的安全性、耐受性、药代动力学和药效学效应:一项在健康受试者中进行的单次递增剂量研究

Conley, Alexander C; Key, Alexandra P; Blackford, Jennifer U; Russell, Jason K; Albert, Kimberly M; Gong, Xuewen; Bubser, Michael; Rook, Jerri M; Conn, P Jeffrey; Lindsley, Craig W; Jones, Carrie K; Newhouse, Paul A

Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)

选择性和中枢神经系统渗透性炔基TREK抑制剂的优化:ONO-9517601 (VU6022856) 和 ONO-7927846 (VU6024391) 的发现和表征

Tanaka, Motoyuki; Sekioka, Yoko; Hashimoto, Gakuji; Mori, Takahiro; Shono, Tomoyuki; Isaji, Yuuki; Hisaichi, Katsuya; Childress, Elizabeth S; Bollinger, Sean; Schmitt, Joza A; Chopko, Trevor C; Garrison, Aaron T; Perry, Charles K; Chronister, Keagan; Kramer, Meghan; Chang, Sichen; Watson, Katherine J; Dickerson, Jonathan W; Bubser, Michael; Rook, Jerri M; Jones, Carrie K; Boutaud, Olivier; Bridges, Thomas M; Denton, Jerod S; Engers, Darren W; Kurata, Haruto; Lindsley, Craig W

Better the devil you know: sympatric fish host copes better than allopatric with a myxozoan parasite

宁愿选择熟悉的魔鬼:同域鱼类宿主比异域鱼类宿主更能适应粘孢子虫寄生虫

Estensoro, Itziar; López-Gurillo, Beatriz; Tafalla, Carolina; Craig, Ryan; Atkinson, Stephen; Sitjà-Bobadilla, Ariadna; Bartholomew, Jerri

Genetic Diversity and Nodulation Potential of Bradyrhizobium Strains in Cowpea and Soybean

豇豆和大豆中慢生根瘤菌菌株的遗传多样性和结瘤潜力

Pereira de Moraes Carvalho, Camila; Oliveira, Alberto Fernandes Jr; Rouws, Luc Felicianus Marie; Dos Santos Dourado, Fernanda; Reed Rodrigues Coelho, Marcia; Alves, Bruno José Rodrigues; Zilli, Jerri Édson

Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

噻吩并[3,2-b]吡啶-5-甲酰胺和2,3-二氟苯甲酰胺作为代谢型谷氨酸受体5亚型的负变构调节剂的发现

Crocker, Katherine E; Henderson, Scott H; Capstick, Rory A; Whomble, David L; Bender, Aaron M; Felts, Andrew S; Han, Changho; Engers, Julie L; Billard, Natasha B; Maurer, Mallory A; Cho, Hyekyung P; Rodriguez, Alice L; Niswender, Colleen M; O'Neill, Jordan; Watson, Katherine J; Chang, Sichen; Blobaum, Anna L; Boutaud, Olivier; Peng, Weimin; Rook, Jerri M; Conn, P Jeffrey; Lindsley, Craig W; Temple, Kayla J