日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein

构象限制决定了多药外排衔接蛋白的抑制

Benjamin Russell Lewis, Muhammad R Uddin, Mohammad Moniruzzaman, Katie M Kuo, Anna J Higgins, Laila M N Shah, Frank Sobott, Jerry M Parks, Dietmar Hammerschmid, James C Gumbart, Helen I Zgurskaya, Eamonn Reading

Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling

纤溶酶原-苹果-线虫 (PAN) 结构域中的核心半胱氨酸残基对于 HGF/c-MET 信号传导至关重要

Debjani Pal #, Kuntal De #, Carly M Shanks, Kai Feng, Timothy B Yates, Jennifer Morrell-Falvey, Russell B Davidson, Jerry M Parks, Wellington Muchero

Hit Expansion of a Noncovalent SARS-CoV-2 Main Protease Inhibitor

非共价 SARS-CoV-2 主要蛋白酶抑制剂的命中扩增

Jens Glaser, Ada Sedova, Stephanie Galanie, Daniel W Kneller, Russell B Davidson, Elvis Maradzike, Sara Del Galdo, Audrey Labbé, Darren J Hsu, Rupesh Agarwal, Dmytro Bykov, Arnold Tharrington, Jerry M Parks, Dayle M A Smith, Isabella Daidone, Leighton Coates, Andrey Kovalevsky, Jeremy C Smith

Analysis of Orthogonal Efflux and Permeation Properties of Compounds Leads to the Discovery of New Efflux Pump Inhibitors

化合物的正交流出和渗透特性分析导致发现新的流出泵抑制剂

Mohammad Moniruzzaman, Connor J Cooper, Muhammad R Uddin, John K Walker, Jerry M Parks, Helen I Zgurskaya

Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance

抗肿瘤T细胞免疫有助于胰腺癌的免疫抵抗

Reham Ajina ,Zoe X Malchiodi ,Allison A Fitzgerald ,Annie Zuo ,Shangzi Wang ,Maha Moussa ,Connor J Cooper ,Yue Shen ,Quentin R Johnson ,Jerry M Parks ,Jeremy C Smith ,Marta Catalfamo ,Elana J Fertig ,Sandra A Jablonski ,Louis M Weiner

Mechanistic Duality of Bacterial Efflux Substrates and Inhibitors: Example of Simple Substituted Cinnamoyl and Naphthyl Amides

细菌流出底物和抑制剂的机制二元性:简单取代的肉桂酰和萘基酰胺的例子

Napoleon D'Cunha, Mohammad Moniruzzaman, Keith Haynes, Giuliano Malloci, Connor J Cooper, Enrico Margiotta, Attilio V Vargiu, Muhammad R Uddin, Inga V Leus, Feng Cao, Jerry M Parks, Valentin V Rybenkov, Paolo Ruggerone, Helen I Zgurskaya, John K Walker

Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold

发现具有新型化学支架的多药外排泵抑制剂

Adam T Green, Mohammad Moniruzzaman, Connor J Cooper, John K Walker, Jeremy C Smith, Jerry M Parks, Helen I Zgurskaya

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli

增强大肠杆菌抗生素活性的新型化合物的鉴定和构效关系

Keith M Haynes, Narges Abdali, Varsha Jhawar, Helen I Zgurskaya, Jerry M Parks, Adam T Green, Jerome Baudry, Valentin V Rybenkov, Jeremy C Smith, John K Walker

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump

复兴抗生素:与 AcrA(AcrAB-TolC 多药外排泵的膜融合蛋白)相互作用的外排泵抑制剂

Narges Abdali, Jerry M Parks, Keith M Haynes, Julie L Chaney, Adam T Green, David Wolloscheck, John K Walker, Valentin V Rybenkov, Jerome Baudry, Jeremy C Smith, Helen I Zgurskaya