日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer

一种靶向端粒的药物可以清除小细胞肺癌中的癌细胞起始细胞并促进抗肿瘤免疫。

Buse Eglenen-Polat # ,Ryan R Kowash # ,Hai-Cheng Huang ,Silvia Siteni ,Mingrui Zhu ,Kenian Chen ,Matthew E Bender ,Ilgen Mender ,Victor Stastny ,Benjamin J Drapkin ,Prithvi Raj ,John D Minna ,Lin Xu ,Jerry W Shay ,Esra A Akbay

A Phosphatidyl Conjugated Telomerase-Dependent Telomere-Targeting Nucleoside Demonstrates Colorectal Cancer Direct Killing and Immune Signaling

磷脂酰结合端粒酶依赖性端粒靶向核苷表现出对结直肠癌的直接杀伤和免疫信号传导

Merve Yilmaz, Sibel Goksen, Ilgen Mender, Gunes Esendagli, Sefik Evren Erdener, Alessandra Ahmed, Ates Kutay Tenekeci, Larisa L Birichevskaya, Sergei M Gryaznov, Jerry W Shay, Z Gunnur Dikmen

Radioprotective effect of the anti-diabetic drug metformin

抗糖尿病药物二甲双胍的放射保护作用

Silvia Siteni, Summer Barron, Krishna Luitel, Jerry W Shay

Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex

流感病毒 mRNA 编码通过细胞 TREX-2 复合物进行核输出的决定因素

Prasanna Bhat, Vasilisa Aksenova, Matthew Gazzara, Emily A Rex, Sadaf Aslam, Christina Haddad, Shengyan Gao, Matthew Esparza, Tolga Cagatay, Kimberly Batten, Sara S El Zahed, Alexei Arnaoutov, Hualin Zhong, Jerry W Shay, Blanton S Tolbert, Mary Dasso, Kristen W Lynch, Adolfo García-Sastre, Beatriz M

Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

端粒替代延长 (ALT) 细胞的生存能力依赖于富含 C 的端粒 RNA

Ilaria Rosso #, Corey Jones-Weinert #, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre', Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W Shay, Ciro Mercurio, Fabrizio d'Adda di Fagagna

Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly

SARNP 和 DDX39B 高阶复合物促进 mRNP 组装的结构基础

Yihu Xie, Shengyan Gao, Ke Zhang, Prasanna Bhat, Bradley P Clarke, Kimberly Batten, Menghan Mei, Matthew Gazzara, Jerry W Shay, Kristen W Lynch, Alexia E Angelos, Pate S Hill, Austin L Ivey, Beatriz M A Fontoura, Yi Ren

Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma

利用端粒酶介导的端粒靶向治疗激活肝细胞癌的适应性免疫反应

Ilgen Mender, Silvia Siteni, Summer Barron, Ann Marie Flusche, Naoto Kubota, Chunhua Yu, Crystal Cornelius, Enzo Tedone, Mazvita Maziveyi, Anthony Grichuk, Niranjan Venkateswaran, Maralice Conacci-Sorrell, Yujin Hoshida, Rui Kang, Daolin Tang, Sergei Gryaznov, Jerry W Shay

The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer

胆固醇摄取调节剂 PCSK9 可促进 APC/KRAS 突变型结直肠癌的发生,并且是该病的治疗靶点

Chi Chun Wong, Jian-Lin Wu, Fenfen Ji, Wei Kang, Xiqing Bian, Huarong Chen, Lam-Shing Chan, Simson Tsz Yat Luk, Samuel Tong, Jiaying Xu, Qiming Zhou, Dabin Liu, Hao Su, Hongyan Gou, Alvin Ho-Kwan Cheung, Ka Fai To, Zongwei Cai, Jerry W Shay, Jun Yu

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging

端粒的 DNA 损伤反应在衰老过程中促进了 SARS-CoV-2 受体 ACE2 的转录

Sara Sepe #, Francesca Rossiello #, Valeria Cancila, Fabio Iannelli, Valentina Matti, Giada Cicio, Matteo Cabrini, Eugenia Marinelli, Busola R Alabi, Alessia di Lillo, Arianna Di Napoli, Jerry W Shay, Claudio Tripodo, Fabrizio d'Adda di Fagagna

Resistance to mutant KRASV12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line

hTERT/Cdk4 永生化正常人支气管上皮细胞系对突变型 KRASV12 诱导的衰老具有抵抗力

Nao Muraki, Mizuki Yamada, Hinako Doki, Riho Nakai, Kazuki Komeda, Daiki Goto, Nozomi Kawabe, Kohei Matsuoka, Miyoko Matsushima, Tsutomu Kawabe, Ichidai Tanaka, Masahiro Morise, Jerry W Shay, John D Minna, Mitsuo Sato