日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GUK1 activation is a metabolic liability in lung cancer

GUK1激活是肺癌的一种代谢缺陷

Jaime L Schneider,Kiran Kurmi,Yutong Dai,Ishita Dhiman,Shakchhi Joshi,Brandon M Gassaway,Christian W Johnson,Nicole Jones,Zongyu Li,Christian P Joschko,Toshio Fujino,Joao A Paulo,Satoshi Yoda,Gerard Baquer,Daniela Ruiz,Sylwia A Stopka,Liam Kelley,Andrew Do,Mari Mino-Kenudson,Lecia V Sequist,Jessica J Lin,Nathalie Y R Agar,Steven P Gygi,Kevin M Haigis,Aaron N Hata,Marcia C Haigis

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

LKB1调控JNK依赖性应激信号传导和KRAS突变型肺癌的凋亡依赖性

Chendi Li ,Mohammed Usman Syed ,Anahita Nimbalkar ,Yi Shen ,Melissa D Vieira ,Cameron Fraser ,Zintis Inde ,Xingping Qin ,Jian Ouyang ,Johannes Kreuzer ,Sarah E Clark ,Grace Kelley ,Emily M Hensley ,Robert Morris ,Raul Lazaro ,Brian Belmonte ,Audris Oh ,Makeba Walcott ,Christopher S Nabel ,Sean Caenepeel ,Anne Y Saiki ,Karen Rex ,J Russell Lipford ,Rebecca S Heist ,Jessica J Lin ,Wilhelm Haas ,Kristopher Sarosiek ,Paul E Hughes ,Aaron N Hata

NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations

NVL-655 是一种选择性、脑渗透性抑制剂,可抑制多种 ALK 突变癌蛋白,包括劳拉替尼耐药化合物突变

Jessica J Lin #, Joshua C Horan #, Anupong Tangpeerachaikul #, Aurélie Swalduz, Augusto Valdivia, Melissa L Johnson, Benjamin Besse, D Ross Camidge, Toshio Fujino, Satoshi Yoda, Linh Nguyen-Phuong, Hayato Mizuta, Ludovic Bigot, Catline Nobre, Jii Bum Lee, Mi Ra Yu, Scot Mente, Yuting Sun, Nancy E Ko

Therapy-induced APOBEC3A drives evolution of persistent cancer cells

治疗诱导的APOBEC3A驱动持续性癌细胞的进化

Hideko Isozaki ,Ramin Sakhtemani ,Ammal Abbasi ,Naveed Nikpour ,Marcello Stanzione ,Sunwoo Oh ,Adam Langenbucher ,Susanna Monroe ,Wenjia Su ,Heidie Frisco Cabanos ,Faria M Siddiqui ,Nicole Phan ,Pégah Jalili ,Daria Timonina ,Samantha Bilton ,Maria Gomez-Caraballo ,Hannah L Archibald ,Varuna Nangia ,Kristin Dionne ,Amanda Riley ,Matthew Lawlor ,Mandeep Kaur Banwait ,Rosemary G Cobb ,Lee Zou ,Nicholas J Dyson ,Christopher J Ott ,Cyril Benes ,Gad Getz ,Chang S Chan ,Alice T Shaw ,Justin F Gainor ,Jessica J Lin ,Lecia V Sequist ,Zofia Piotrowska ,Beow Y Yeap ,Jeffrey A Engelman ,Jake June-Koo Lee ,Yosef E Maruvka ,Rémi Buisson ,Michael S Lawrence # ,Aaron N Hata #

Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation

通过新型 KRAS Switch-II 口袋突变和多克隆变异(以 RAS-MAPK 再激活为中心)获得对 KRASG12C 抑制的临床获得性耐药性

Noritaka Tanaka #, Jessica J Lin #, Chendi Li #, Meagan B Ryan, Junbing Zhang, Lesli A Kiedrowski, Alexa G Michel, Mohammed U Syed, Katerina A Fella, Mustafa Sakhi, Islam Baiev, Dejan Juric, Justin F Gainor, Samuel J Klempner, Jochen K Lennerz, Giulia Siravegna, Liron Bar-Peled, Aaron N Hata, Rebecc

Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer

ROS1 融合阳性肺癌对克唑替尼和劳拉替尼的耐药机制

Jessica J Lin #, Noura J Choudhury #, Satoshi Yoda #, Viola W Zhu, Ted W Johnson, Ramin Sakhtemani, Ibiayi Dagogo-Jack, Subba R Digumarthy, Charlotte Lee, Andrew Do, Jennifer Peterson, Kylie Prutisto-Chang, Wafa Malik, Harper G Hubbeling, Adam Langenbucher, Adam J Schoenfeld, Christina J Falcon, Jen

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

针对晚期黑色素瘤、非小细胞肺癌或膀胱癌患者的个性化新抗原疗法联合抗 PD-1 治疗的 Ib 期试验

Patrick A Ott, Siwen Hu-Lieskovan, Bartosz Chmielowski, Ramaswamy Govindan, Aung Naing, Nina Bhardwaj, Kim Margolin, Mark M Awad, Matthew D Hellmann, Jessica J Lin, Terence Friedlander, Meghan E Bushway, Kristen N Balogh, Tracey E Sciuto, Victoria Kohler, Samantha J Turnbull, Rana Besada, Riley R Cu

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

RET 溶剂前沿突变介导 RET 驱动的恶性肿瘤对选择性 RET 抑制产生获得性耐药性

Benjamin J Solomon, Lavinia Tan, Jessica J Lin, Stephen Q Wong, Sebastian Hollizeck, Kevin Ebata, Brian B Tuch, Satoshi Yoda, Justin F Gainor, Lecia V Sequist, Geoffrey R Oxnard, Oliver Gautschi, Alexander Drilon, Vivek Subbiah, Christine Khoo, Edward Y Zhu, Michele Nguyen, Dahlia Henry, Kevin R Con

Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer

序贯 ALK 抑制剂可在 ALK 阳性肺癌中筛选出对劳拉替尼具有耐药性的化合物 ALK 突变

Satoshi Yoda, Jessica J Lin, Michael S Lawrence, Benjamin J Burke, Luc Friboulet, Adam Langenbucher, Leila Dardaei, Kylie Prutisto-Chang, Ibiayi Dagogo-Jack, Sergei Timofeevski, Harper Hubbeling, Justin F Gainor, Lorin A Ferris, Amanda K Riley, Krystina E Kattermann, Daria Timonina, Rebecca S Heist,