Jevnikar Zala相关文献与解析，生知库 | 链接生命科学的每一步

Lässer, Cecilia; Ax, Elisabeth; Weidner, Julie; Winslow, Sofia; Ingelhag, Hannes; Calvén, Jenny; Malmhäll, Carina; Jevnikar, Zala; Olsson, Henric; Rådinger, Madeleine

炎症/感染

炎症

发表日期：2026

文献求助收藏

Phase 2a randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of londamocitinib (AZD4604) two times per day for 12 weeks in adult patients with moderate-to-severe asthma uncontrolled on medium-high-dose ICS-LABA

一项 IIa 期随机、双盲、安慰剂对照研究，旨在评估 londamocitinib (AZD4604) 每日两次，持续 12 周，治疗中高剂量吸入性糖皮质激素-长效β2受体激动剂 (ICS-LABA) 控制不佳的中重度哮喘成人患者的疗效和安全性。

期刊:Bmj Open Respiratory Research

影响因子:3.4

doi:10.1136/bmjresp-2025-003589

Mustapa, Mohd Nubli; Hughes, Rod; Jensen, Tina J; Dosanjh, Davinder P; Konstantinidis, Kyriakos V; Jonsson, Julia; Nemes, Szilárd; Jevnikar, Zala; Jones, Michael; Adams, Amanda; Belvisi, Maria G; Akuthota, Praveen; Kocks, Janwillem W H

AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma

AZD0449（一种吸入式JAK1抑制剂）在健康受试者和轻度哮喘患者中进行研究

期刊:British Journal of Clinical Pharmacology

影响因子:3

doi:10.1002/bcp.70262

Lundahl, Anna; Hughes, Rod; Almquist, Joachim; Close, David; Mäenpää, Jukka; Tehler, Ulrika; Jensen, Tina Jellesmark; Nemes, Szilárd; Mercier, Anne-Kristina; Jevnikar, Zala; Soto, Pablo Forte; Singh, Dave

ARTEMISIA: a mechanistic study of a novel Janus kinase 1 inhibitor to advance molecular understanding and precision medicine in asthma

ARTEMISIA：一项关于新型 Janus 激酶 1 抑制剂的机制研究，旨在增进对哮喘分子机制的理解并促进精准医疗。

期刊:Respiratory Research

影响因子:5

doi:10.1186/s12931-025-03309-3

Dosanjh, Davinder Paul Singh; Darrah, Erika; Jensen, Tina Jellesmark; Jevnikar, Zala; Halvorson, Alese; Cardner, Mathias; Hughes, Rod; Grant, Sarah S; Platt, Adam; Brightling, Chris E

Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells.

组织蛋白酶 H 介导 talin 的加工，并调节前列腺癌细胞的迁移

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.M112.436394

Jevnikar Zala, Rojnik Matija, Jamnik Polona, Doljak Bojan, Fonovic UrÅ¡a PeÄar, Kos Janko

Profilin 1 as a target for cathepsin X activity in tumor cells.

Profilin 1 作为肿瘤细胞中组织蛋白酶 X 活性的靶点

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0053918

PeÄar FonoviÄ UrÅ¡a, Jevnikar Zala, Rojnik Matija, Doljak Bojan, FonoviÄ Marko, Jamnik Polona, Kos Janko

Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines

组织蛋白酶H间接调控多种人类细胞系中的形态发生蛋白-4 (BMP-4)

期刊:Radiology and Oncology

影响因子:2.2

doi:10.2478/v10019-011-0034-3

Rojnik, Matija; Jevnikar, Zala; Mirkovic, Bojana; Janes, Damjan; Zidar, Nace; Kikelj, Danijel; Kos, Janko

The role of cathepsin X in cell signaling

组织蛋白酶X在细胞信号传导中的作用

期刊:Cell Adhesion & Migration

影响因子:3.5

doi:10.4161/cam.3.2.7403

Kos, Janko; Jevnikar, Zala; Obermajer, Natasa

Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins

半胱氨酸蛋白酶组织蛋白酶X通过激活β2整合素调节免疫反应。

期刊:Immunology

影响因子:5

doi:10.1111/j.1365-2567.2007.02740.x

Obermajer, Natasa; Repnik, Urska; Jevnikar, Zala; Turk, Boris; Kreft, Marko; Kos, Janko

免疫/内分泌

发表日期：2008

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The involvement of Th17 inflammation and miR-363-3p in airway epithelial barrier dysfunction

Th17炎症和miR-363-3p参与气道上皮屏障功能障碍

Phase 2a randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of londamocitinib (AZD4604) two times per day for 12 weeks in adult patients with moderate-to-severe asthma uncontrolled on medium-high-dose ICS-LABA

一项 IIa 期随机、双盲、安慰剂对照研究，旨在评估 londamocitinib (AZD4604) 每日两次，持续 12 周，治疗中高剂量吸入性糖皮质激素-长效β2受体激动剂 (ICS-LABA) 控制不佳的中重度哮喘成人患者的疗效和安全性。

AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma

AZD0449（一种吸入式JAK1抑制剂）在健康受试者和轻度哮喘患者中进行研究

ARTEMISIA: a mechanistic study of a novel Janus kinase 1 inhibitor to advance molecular understanding and precision medicine in asthma

ARTEMISIA：一项关于新型 Janus 激酶 1 抑制剂的机制研究，旨在增进对哮喘分子机制的理解并促进精准医疗。

Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells.

组织蛋白酶 H 介导 talin 的加工，并调节前列腺癌细胞的迁移

Profilin 1 as a target for cathepsin X activity in tumor cells.

Profilin 1 作为肿瘤细胞中组织蛋白酶 X 活性的靶点

Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines

组织蛋白酶H间接调控多种人类细胞系中的形态发生蛋白-4 (BMP-4)

The role of cathepsin X in cell signaling

组织蛋白酶X在细胞信号传导中的作用

Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins

半胱氨酸蛋白酶组织蛋白酶X通过激活β2整合素调节免疫反应。