日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial

BCMA靶向mRNA CAR T细胞疗法治疗重症肌无力:一项随机、双盲、安慰剂对照的2b期试验

Vu, Tuan; Durmus, Hacer; Rivner, Michael; Shroff, Sheetal; Ragole, Thomas; Myers, Bennett; Pasnoor, Mamatha; Small, George; Karam, Chafic; Vullaganti, Mithila; Peltier, Amanda; Sahagian, Gregory; Feinberg, Marc H; Slanksy, Adam; Barnett-Tapia, Carolina; Siddiqi, Zaeem; Gwathmey, Kelly; Badruddoja, Michael A; Kamboh, Hafsa; Ruggerie, Rachel N; Fedak, Renee R; Stewart, C Andrew; Kurtoglu, Metin; Kalayoglu, Murat; Singer, Michael; Jewell, Christopher M; Miljkovic, Milos D; Dimachkie, Mazen; Mozaffar, Tahseen; Howard, James F Jr

BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial.

BCMA 靶向 mRNA CAR-T 细胞疗法治疗重症肌无力:安慰剂对照 2b 期试验的探索性生物标志物分析。

Fedak Renee R, Ruggerie Rachel N, Shan Yufei, Curvino Elizabeth J, de Sousa Juliana F, Daniel Shaji, Ngo-Casi Minhtran, Kamboh Hafsa, Vu Tuan, Durmuş Hacer, Mozaffar Tahseen, Howard James F Jr, English Emily P, Benson Albina, Duvernay Matthew T, Singer Michael S, Kalayoglu Murat V, Brunn Carsten, Bodansky Aaron, Anderson Mark S, DeRisi Joseph L, Garcia Samantha T, Yu David J L, Zorn Kelsey C, Kurtoglu Metin, Miljković Miloš D, Stewart C Andrew, Jewell Christopher M

Defined distribution and features of lymph node therapies enable recruitment and manipulation of antigen-specific T cell response

淋巴结疗法的明确分布和特征能够募集和调控抗原特异性T细胞反应。

Tsai, Shannon J; Kapnick, Senta M; Carey, Sean T; McIlvaine, Ryan A; Rui, Yuan; Eppler, Haleigh B; Shah, Shrey A; Bridgeman, Christopher J; Yanes, Alexis A; Black, Sheneil K; Zeng, Xiangbin; Gammon, Joshua M; Jewell, Christopher M

Local control of T cell fate in lymph nodes safely and durably reverses myelin-driven autoimmunity

淋巴结内T细胞命运的局部控制可安全持久地逆转髓鞘驱动的自身免疫

Kapnick, Senta M; Gosselin, Emily A; Tsai, Shannon J; Oakes, Robert S; Habibabady, Zahra A; Ackun-Farmmer, Marian A; Carey, Sean T; Shah, Shrey A; Shen, Ruochen; Froimchuk, Eugene; Eppler, Haleigh B; Bridgeman, Christopher J; Yanes, Alexis A; McIlvaine, Ryan A; Noshin, Maeesha; Tostanoski, Lisa H; Black, Sheneil K; Zeng, Xiangbin; Azimzadeh, Agnes; Pierson, Richard N 3rd; Bromberg, Jonathan S; Jewell, Christopher M

Regulation of response to antigen peptides is independent of peptide distribution in lymph node therapeutics

淋巴结治疗中对抗原肽的反应调节与肽的分布无关

McIlvaine, Ryan A; Kapnick, Senta M; Carey, Sean T; Jewell, Christopher M

Durability of Response to B-Cell Maturation Antigen-Directed mRNA Cell Therapy in Myasthenia Gravis

重症肌无力患者对B细胞成熟抗原导向的mRNA细胞疗法的反应持久性

Chahin, Nizar; Sahagian, Gregory; Feinberg, Marc H; Stewart, C Andrew; Jewell, Christopher M; Kurtoglu, Metin; Miljković, Miloš D; Vu, Tuan; Mozaffar, Tahseen; Howard, James F Jr

Bacterial extracellular vesicles as a tunable platform for vaginal drug delivery

细菌细胞外囊泡作为阴道给药的可调控平台

Steinman, Darby; Sri Hemanth Kumar, Varunaa; McIlvaine, Ryan A; Tyagi, Pranshu; Kang, Hahnbit; Alam, Raifah; Liu, Anguo; Jewell, Christopher M; Burd, Irina; Molinari, Sara; Zierden, Hannah C

PEGylation strategies for enhanced nanoparticle delivery to tumor associated immune cells

聚乙二醇化策略可增强纳米颗粒向肿瘤相关免疫细胞的递送

Cahn, Devorah; Pal, Sanjay; Patel, Nimit L; Gower, Timothy; Kapnick, Senta M; Jewell, Christopher M; Duncan, Gregg A; Wolf, Matthew T

Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin

利用生物材料控制皮肤组织、细胞和分子水平的免疫信号传导,推进免疫疗法

Shah, Shrey A; Oakes, Robert S; Jewell, Christopher M

Engineering metabolism to modulate immunity

通过基因工程改造代谢以调节免疫力

Kapnick, Senta M; Martin, Corinne A; Jewell, Christopher M