日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV(+) tumors

合理安排WEE1抑制剂的治疗方案可以保护T细胞功能,并促进对HPV(+)肿瘤的免疫控制。

Liu, Ying; Zhang, Zhiheng; Tao, Yanshan; Rahgav, Lovely; Gray-Gaillard, Sophie; Hussaini, Yasser; Pan, Meijie; Shamber, Justine; Kwak, Jeff; Park, Simone L; Cramer, Jessica; Stoltz, Regina; Patria, Joseph; Swanger, Jherek; Liu, Kathryn; Sannigrahi, Malay Kumar; Houghton, A McGarry; Rodriguez, Cristina P; Carey, Ryan M; Brody, Robert; Rajasekaran, Karthik; Weinstein, Gregory; Linette, Gerald P; Carreno, Beatriz M; Painter, Mark M; Wherry, E John; Clurman, Bruce; Basu, Devraj; Diab, Ahmed

Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor

两个二磷酸化的降解信号通过Fbw7肿瘤抑制因子控制c-Myc的降解

Markus Welcker ,Baiyun Wang ,Domniţa-Valeria Rusnac ,Yasser Hussaini ,Jherek Swanger ,Ning Zheng ,Bruce E Clurman

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

致癌性Fbw7突变的全局性和特定情境下的转录后果

H Nayanga Thirimanne ,Feinan Wu ,Derek H Janssens ,Jherek Swanger ,Ahmed Diab ,Heather M Feldman ,Robert A Amezquita ,Raphael Gottardo ,Patrick J Paddison ,Steven Henikoff ,Bruce E Clurman

A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation

原位磷酸化揭示人类核 CDK2 底物的新格局

Yong Chi, John H Carter, Jherek Swanger, Alexander V Mazin, Robert L Moritz, Bruce E Clurman

FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition

FOXM1 驱动 HPV+ HNSCC 对 WEE1 抑制的敏感性

Ahmed Diab, Hakan Gem, Jherek Swanger, Hee Yeon Kim, Kaleb Smith, Grace Zou, Sharat Raju, Michael Kao, Matthew Fitzgibbon, Keith R Loeb, Cristina P Rodriguez, Eduardo Méndez, Denise A Galloway, Julia M Sidorova, Bruce E Clurman

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism

预测致癌突变的泛癌转录特征表明,Fbw7 调控癌细胞的氧化代谢。

Davis, Ryan J; Gönen, Mehmet; Margineantu, Daciana H; Handeli, Shlomo; Swanger, Jherek; Hoellerbauer, Pia; Paddison, Patrick J; Gu, Haiwei; Raftery, Daniel; Grim, Jonathan E; Hockenbery, David M; Margolin, Adam A; Clurman, Bruce E

The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation

PP2A-B56磷酸酶通过位点特异性去磷酸化作用抑制细胞周期蛋白E的自催化降解

Ryan J Davis ,Jherek Swanger ,Bridget T Hughes ,Bruce E Clurman

Fbw7 dimerization determines the specificity and robustness of substrate degradation

Fbw7二聚化决定了底物降解的特异性和稳定性

Welcker, Markus; Larimore, Elizabeth A; Swanger, Jherek; Bengoechea-Alonso, Maria T; Grim, Jonathan E; Ericsson, Johan; Zheng, Ning; Clurman, Bruce E

Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase

细胞周期蛋白A-细胞周期蛋白依赖性激酶2对真核延伸因子2 (eEF2) 的磷酸化调节eEF2激酶对其的抑制作用。

Hizli, Asli A; Chi, Yong; Swanger, Jherek; Carter, John H; Liao, Yi; Welcker, Markus; Ryazanov, Alexey G; Clurman, Bruce E

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

SCF-Fbw7 泛素连接酶降解 MED13 和 MED13L 并调节 CDK8 模块与 Mediator 的关联

Michael A Davis, Elizabeth A Larimore, Brian M Fissel, Jherek Swanger, Dylan J Taatjes, Bruce E Clurman