日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach

利用 ANXA1 提高 CHO 细胞中重组蛋白的产量：一种 UPR 介导的生物加工方法

期刊:Synthetic and Systems Biotechnology
影响因子:4.4
doi:10.1016/j.synbio.2025.12.001
Zhao, Qi; Zhang, Hui-Jie; Han, Ming-Ming; Abiti, Jumai; Dong, Yan-Ju; Wang, Jia-Ning; Lu, Jiang-Tao; Wang, Wen; Zhang, Xi; Geng, Shao-Lei; Qiu, Le-Le; Wang, Xiao-Yin; Hua, Zi-Chun; Wang, Tian-Yun; Jia, Yan-Long
ANXA1
细胞生物学
发表日期：2026
文献求助 收藏

Epigenetic regulation of histone methyltransferase SUV39H1 on the expression of recombinant protein in CHO cells.

组蛋白甲基转移酶SUV39H1的表观遗传调控对CHO细胞中重组蛋白表达的影响

期刊:Applied Microbiology and Biotechnology
影响因子:4.3
doi:10.1007/s00253-025-13509-y
Yang Lu-Lu, Zhang Miao, Guo Jia-Liang, Han Ming-Ming, Qiu Le-Le, Gao Li-Jie, Cui Liu-Su, Wang Xiao-Yin, Wang Tian-Yun, Jia Yan-Long
表观遗传
发表日期：2025
文献求助 收藏

SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing.

SETDB1 敲低通过表观遗传转录沉默增强 CHO 细胞中的重组蛋白

期刊:AMB Express
影响因子:3.7
doi:10.1186/s13568-025-01914-5
Lu Jiang-Tao, Zhang Miao, Gao Yan-Ping, Yang Lu-Lu, Cui Zhao-Ming, Han Ming-Ming, Zhang Xi, Xu Hong-Yan, Wang Xiao-Yin, Qiu Le-Le, Hua Zi-Chun, Wang Tian-Yun, Jia Yan-Long
表观遗传
发表日期：2025
文献求助 收藏

Enhanced Transgene Expression by Optimization of Poly A in Transfected CHO Cells

通过优化转染CHO细胞中的Poly A增强转基因表达

期刊:Frontiers in Bioengineering and Biotechnology
影响因子:4.8
doi:10.3389/fbioe.2022.722722
Wang, Xiao-Yin; Du, Qiu-Jie; Zhang, Wei-Li; Xu, Dan-Hua; Zhang, Xi; Jia, Yan-Long; Wang, Tian-Yun
细胞生物学
发表日期：2022
文献求助 收藏

Stabilizing and Anti-Repressor Elements Effectively Increases Transgene Expression in Transfected CHO Cells

稳定元件和抗阻遏元件可有效提高转染CHO细胞中转基因的表达。

期刊:Frontiers in Bioengineering and Biotechnology
影响因子:4.8
doi:10.3389/fbioe.2022.840600
Li, Qin; Yan, Rui-Fang; Yang, Yong-Xiao; Mi, Chun-Liu; Jia, Yan-Long; Wang, Tian-Yun
细胞生物学
发表日期：2022
文献求助 收藏

Effect of promoter, promoter mutation and enhancer on transgene expression mediated by episomal vectors in transfected HEK293, Chang liver and primary cells

启动子、启动子突变和增强子对转染HEK293、Chang肝细胞和原代细胞中游离型载体介导的转基因表达的影响

期刊:Bioengineered
影响因子:4.2
doi:10.1080/21655979.2019.1684863
Xu, Zhong-Jie; Jia, Yan-Long; Wang, Meng; Yi, Dan-Dan; Zhang, Wei-Li; Wang, Xiao-Yin; Zhang, Jun-He
细胞生物学
发表日期：2019
文献求助 收藏

SV40 intron, a potent strong intron element that effectively increases transgene expression in transfected Chinese hamster ovary cells

SV40内含子是一种强效内含子元件，能有效提高转染的中国仓鼠卵巢细胞中转基因的表达。

期刊:Journal of Cellular and Molecular Medicine
影响因子:4.2
doi:10.1111/jcmm.13504
Xu, Dan-Hua; Wang, Xiao-Yin; Jia, Yan-Long; Wang, Tian-Yun; Tian, Zheng-Wei; Feng, Xin; Zhang, Yin-Na
细胞生物学
发表日期：2018
文献求助 收藏

CRISPR/Cas9-mediated gene knockout for DNA methyltransferase Dnmt3a in CHO cells displays enhanced transgenic expression and long-term stability

利用 CRISPR/Cas9 介导的基因敲除 CHO 细胞中的 DNA 甲基转移酶 Dnmt3a，可增强转基因表达并维持长期稳定性。

期刊:Journal of Cellular and Molecular Medicine
影响因子:4.2
doi:10.1111/jcmm.13687
Jia, Yan-Long; Guo, Xiao; Lu, Jiang-Tao; Wang, Xiao-Yin; Qiu, Le-Le; Wang, Tian-Yun
细胞生物学
发表日期：2018
文献求助 收藏

A chimeric HS4 insulator-scaffold attachment region enhances transgene expression in transfected Chinese hamster ovary cells

嵌合的HS4绝缘体-支架连接区增强了转染的中国仓鼠卵巢细胞中的转基因表达。

期刊:FEBS Open Bio
影响因子:2.3
doi:10.1002/2211-5463.12335
Chen, Si-Jia; Wang, Wen; Zhang, Feng-Yi; Jia, Yan-Long; Wang, Xiao-Yin; Guo, Xiao; Chen, Shao-Nan; Gao, Jian-Hui; Wang, Tian-Yun
细胞生物学
发表日期：2017
文献求助 收藏