PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis.
PTEN 缺失促进 PI3Kβ 磷酸化和 EPHA2/SRC/p-PI3KβY962 复合物组装,从而驱动肿瘤发生。
期刊:Cancer Discovery
影响因子:33.3
doi:10.1158/2159-8290.CD-25-1126
Tang Shuang, Zhou Qian, Bergholz Johann S, Jiang Tao, Wang Weihua, Ji Renlei, Huang Wendi, Wu Jiachen, Li Yutong, Wan Xiaochun, He Xiadi, Jing Qianchen, Sun Menghong, Johnson Jared L, Yaron-Barir Tomer M, Li Da-Qiang, Dai Bo, Wang Zefeng, Li Xiaoling, Cantley Lewis C, Roberts Thomas M, Zhao Jean J
肿瘤
SRC
PTEN
EPHA2
PI3K/Akt
磷酸化