日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bacterial pathogens hijack host cell peroxisomes for replication vacuole expansion and integrity.

细菌病原体劫持宿主细胞过氧化物酶体以进行复制,从而扩大液泡并维持其完整性

Hossain Mohammad J, Romanov Katerina A, Jian Jeffrey, Swaby Louis C, Bandyopadhyay Saumya, Guan Ivan, Thomas Sean M, Olive Andrew J, O'Connor Tamara J

Bacterial type II topoisomerases cleave DNA in a species-specific manner

细菌II型拓扑异构酶以物种特异性方式切割DNA。

Morgan, Ian L; Jian, Jeffrey Y; Osheroff, Neil; Neuman, Keir C

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead

CMX990 的发现:一种带有新型弹头的强效 SARS-CoV-2 3CL 蛋白酶抑制剂

Dayan Elshan, N G R; Wolff, Karen C; Riva, Laura; Woods, Ashley K; Grabovyi, Gennadii; Wilson, Katy; Pedroarena, James; Ghorai, Sourav; Nazarian, Armen; Weiss, Frank; Liu, Yuyin; Mazumdar, Wrickban; Song, Lirui; Okwor, Neechi; Malvin, Jacqueline; Bakowski, Malina A; Beutler, Nathan; Kirkpatrick, Melanie G; Gebara-Lamb, Amal; Huang, Edward; Nguyen-Tran, Vân T B; Chi, Victor; Li, Shuangwei; Rogers, Thomas F; McNamara, Case W; Gupta, Anil Kumar; Rahimi, Alireza; Chen, Jian Jeffrey; Joseph, Sean B; Schultz, Peter G; Chatterjee, Arnab K

Correction to "Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead"

对“CMX990的发现:一种带有新型弹头的强效SARS-CoV-2 3CL蛋白酶抑制剂”一文的更正

Elshan, N G R Dayan; Wolff, Karen C; Riva, Laura; Woods, Ashley K; Grabovyi, Gennadii; Wilson, Katy; Pedroarena, James; Ghorai, Sourav; Nazarian, Armen; Weiss, Frank; Liu, Yuyin; Mazumdar, Wrickban; Song, Lirui; Okwor, Neechi; Malvin, Jacqueline; Liu, Dongdong; Bakowski, Malina A; Beutler, Nathan; Kirkpatrick, Melanie G; Gebara-Lamb, Amal; Huang, Edward; Nguyen-Tran, Vân T B; Chi, Victor; Li, Shuangwei; Rogers, Thomas F; McNamara, Case W; Gupta, Anil Kumar; Rahimi, Alireza; Chen, Jian Jeffrey; Joseph, Sean B; Schultz, Peter G; Chatterjee, Arnab K

Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases

区分左右手:DNA超螺旋手性对II型拓扑异构酶作用的影响

Jian, Jeffrey Y; Osheroff, Neil

Pharmacological YAP activation promotes regenerative repair of cutaneous wounds

药理学 YAP 激活促进皮肤伤口的再生修复

Edyta M Grzelak, N G R Dayan Elshan, Sida Shao, Maya L Bulos, Sean B Joseph, Arnab K Chatterjee, Jian Jeffrey Chen, Vân Nguyên-Trân, Peter G Schultz, Michael J Bollong

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

发现用于治疗实体肿瘤的 KRASG12C (AMG 510) 共价抑制剂

Brian A Lanman, Jennifer R Allen, John G Allen, Albert K Amegadzie, Kate S Ashton, Shon K Booker, Jian Jeffrey Chen, Ning Chen, Michael J Frohn, Guy Goodman, David J Kopecky, Longbin Liu, Patricia Lopez, Jonathan D Low, Vu Ma, Ana E Minatti, Thomas T Nguyen, Nobuko Nishimura, Alexander J Pickrell, A

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

药物再利用:驱虫药氯硝柳胺和硝唑尼特是强效的 TMEM16A 拮抗剂,可完全扩张气道

Kent Miner, Katja Labitzke, Benxian Liu, Paul Wang, Kathryn Henckels, Kevin Gaida, Robin Elliott, Jian Jeffrey Chen, Longbin Liu, Anh Leith, Esther Trueblood, Kelly Hensley, Xing-Zhong Xia, Oliver Homann, Brian Bennett, Mike Fiorino, John Whoriskey, Gang Yu, Sabine Escobar, Min Wong, Teresa L Born, 

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease

抑制细胞粘附蛋白可预防运动神经元疾病的遗传模型

Jinbin Zhai, Lei Zhang, Jelena Mojsilovic-Petrovic, Xiaoying Jian, Jeffrey Thomas, Kengo Homma, Anton Schmitz, Michael Famulok, Hidenori Ichijo, Yair Argon, Paul A Randazzo, Robert G Kalb

An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities

一种口服有效的BACE1抑制剂,可在不产生心血管副作用的情况下显著降低中枢神经系统Aβ水平。

Cheng, Yuan; Brown, James; Judd, Ted C; Lopez, Patricia; Qian, Wenyuan; Powers, Timothy S; Chen, Jian Jeffrey; Bartberger, Michael D; Chen, Kui; Dunn, Robert T 2nd; Epstein, Oleg; Fremeau, Robert T Jr; Harried, Scott; Hickman, Dean; Hitchcock, Stephen A; Luo, Yi; Minatti, Ana Elena; Patel, Vinod F; Vargas, Hugo M; Wahl, Robert C; Weiss, Matthew M; Wen, Paul H; White, Ryan D; Whittington, Douglas A; Zheng, Xiao Mei; Wood, Stephen